Unlock instant, AI-driven research and patent intelligence for your innovation.
Application of substance for knocking down BACE2 gene expression in tumor resistance and BACE2 inhibitor
What is Al technical title?
Al technical title is built by PatSnap Al team. It summarizes the technical point description of the patent document.
A gene expression and anti-tumor technology, applied in the field of biomedicine, can solve the problems of low cure rate and poor pertinence, achieve good therapeutic effect, inhibit proliferation, and have good application prospects
Pending Publication Date: 2022-05-31
湖北亿粲健康产业有限公司
View PDF3 Cites 0 Cited by
Summary
Abstract
Description
Claims
Application Information
AI Technical Summary
This helps you quickly interpret patents by identifying the three key elements:
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more
Image
Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
Click on the blue label to locate the original text in one second.
Reading with bidirectional positioning of images and text.
Smart Image
Examples
Experimental program
Comparison scheme
Effect test
Embodiment 1
The transfection solution was configured according to Table 1. After the cells were transfected for 8 h, the normal medium was replaced, and the culture was continued for 48 h.
2. the six-hole plate is placed on ice, and the isolated protein sample is extracted, and with GAPDH as an internal reference, the detection of the
3. The precultured cells are transfected with transfection solution (same as Example 1), and after 6 hours of transfection, the cells are more
The serum-containing medium was changed, and the culture was continued for 24 h.
4. use the pipette tip to compare with a ruler after the cell is overgrown, try to be perpendicular to the horizontal line scratch on the back, the pipette tip should be vertical, do not
tilt.
[0103] 5. Wash cells 3 times with PBS, remove streaked cells, and add serum-free DMEM medium. Put into 37℃, 5%
CO
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More
PUM
Login to View More
Abstract
The invention provides an application of a substance for knocking down BACE2 gene expression in tumor resistance and a BACE2 inhibitor. The tumor is a colon tumor. According to the invention, the expression of the BACE2 gene is obviously reduced by selecting specific siRNA, and the migration, proliferation and invasion capabilities of tumor cells are effectively inhibited. Therefore, the proliferation of the colon tumor can be effectively inhibited by knocking down the expression of the BACE2 gene, and a new thought is provided for the treatment of the colon tumor.
Description
Application of substances knocking down BACE2 gene expression in anti-tumor and BACE2 inhibitors technical field The present invention relates to the field of biomedicine, be specifically related to the application of the substance that knocks down BACE2 gene expression in antitumor. with BACE2 inhibitors. Background technique Colon tumor is a common malignant tumor in the gastrointestinal tract, and its incidence is second only to gastric and esophageal cancer, and it is the most common cancer Common section. Colorectal cancer is not impossible to prevent. In fact, colorectal cancer is the easiest disease to self-screen. If it can be detected early, it is also The most curable disease. The treatment of colon tumors generally requires surgical resection of the tumor, and at the same time, a tumor adjacent to the tumor should be removed. segment of the bowel and surrounding lymph nodes. However, surgical treatment has the disadvantages of poor targeting and low cur...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More
Application Information
Patent Timeline
Application Date:The date an application was filed.
Publication Date:The date a patent or application was officially published.
First Publication Date:The earliest publication date of a patent with the same application number.
Issue Date:Publication date of the patent grant document.
PCT Entry Date:The Entry date of PCT National Phase.
Estimated Expiry Date:The statutory expiry date of a patent right according to the Patent Law, and it is the longest term of protection that the patent right can achieve without the termination of the patent right due to other reasons(Term extension factor has been taken into account ).
Invalid Date:Actual expiry date is based on effective date or publication date of legal transaction data of invalid patent.
Login to View More 
Login to View More 
