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Modeling method for mouse with complex periodontitis and tooth movement

A technology of tooth movement and modeling method, applied in veterinary surgery, medical science, veterinary instruments, etc., can solve the problem of lack of mouse model, and achieve the effect of being conducive to bacterial retention, great application value and advantages

Active Publication Date: 2022-07-05
HOSPITAL OF STOMATOLOGY SUN YAT SEN UNIV
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  • Claims
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AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to provide a stable and reliable mouse periodontitis with tooth movement modeling method, focusing on solving periodontitis and orthodontic tooth movement The Problem with the Absence of Mouse Models in Sex Research

Method used

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  • Modeling method for mouse with complex periodontitis and tooth movement
  • Modeling method for mouse with complex periodontitis and tooth movement

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Experimental program
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Embodiment 1

[0042]1. Materials

[0043] Twelve 8-week-old C57 / BL6 mice, 24-26 g, were provided by the Animal Center of Sun Yat-sen University and were raised in the SPF environment of the Animal Center of the North Campus of Sun Yat-sen University. This experiment was approved by the Ethics Committee of Sun Yat-sen University. The 6-0 silk braided non-absorbable sutures were supplied by Johnson & Johnson, model Axicomus SA82G. Micro-CT is provided by Swiss scanco medical company, model is micro-CT50, orthodontic chain ring, 0.15mm orthodontic ligature wire.

[0044] 2. Experimental method

[0045] 1. Establishment of a mouse model of compound periodontitis with tooth movement based on the maxillary second molar:

[0046] After 18 C57 / BL6 mice were adaptively fed for one week, the mice were anesthetized with 1.5% sodium pentobarbital intraperitoneally at a dose of 40 mg / kg;

[0047] The mice to be modeled were anesthetized by intraperitoneal anesthesia, and fixed on the rat table in a s...

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Abstract

The invention discloses a composite periodontitis accompanied tooth movement mouse modeling method which comprises the following steps: comprehensively establishing a mouse periodontitis model through rough surgical suture and porphyromonas gingivalis bacterial liquid, and establishing a periodontitis accompanied tooth movement model after confirming that the periodontitis model is successfully established through local periodontal tissue pathological change. On the basis of a mild and injury-free periodontitis model, a unique mouse posterior tooth movement method is combined, pathological changes of periodontal tissues in the correction process under the condition of clinical adult orthodontic treatment with periodontal problems are successfully simulated, and the periodontal position change condition is determined. The invention innovatively provides the mouse model for compounding periodontitis with tooth movement, effectively fills the blank of animal models in the related research field of periodontitis and orthodontic tooth movement, shows great application value in discussing the complicated pathological mechanism associated with periodontitis and orthodontic tooth movement, and broadens the idea and method of the clinical research hotspot.

Description

technical field [0001] The invention relates to the technical field of periodontology and orthodontic treatment, in particular to a method for modeling compound periodontitis with tooth movement in mice. Background technique [0002] Periodontitis is a chronic inflammation of periodontal support tissue caused by various factors, especially dental plaque and calculus. Orthodontic treatment is simply a treatment process in which a series of physiological changes occur in the periodontal tissue caused by mechanical force, so that the teeth are moved to the ideal position physiologically. And with the improvement of people's awareness of health care, the number of adult patients who choose orthodontic treatment is gradually increasing. Due to the high incidence of periodontitis, most of the adult patients receiving orthodontic treatment often have periodontitis. Therefore, in recent years, The impact of periodontitis on periodontal tissue during orthodontic treatment has receiv...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61D1/00
CPCA61D1/00
Inventor 王艺羲
Owner HOSPITAL OF STOMATOLOGY SUN YAT SEN UNIV
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