54 results about "Gingivalis porphyromonas" patented technology

The invention provides pharmaceutical compositions comprising Porphyromonas gingivalis protease and hemagglutinin polypeptides that have anti-angiogenic activity and methods for their use.

The invention relates to generation and use of cellular and humoral responses for the prevention and treatment of P. gingivalis related conditions and diseases.

The present invention relates to isolated Porphyromonas gingivalis polypeptides and nucleotides. The polypeptides include an amino acid sequence selected from the group consisting of: SEQ. ID. NO. 110; SEQ. ID. NO. 111; SEQ. ID. NO. 112; SEQ. ID. NO. 113; SEQ ID NO: 120; SEQ. ID. NO. 123; SEQ. ID. NO. 124; SEQ. ID. NO. 125; SEQ. ID. NO. 130; SEQ. ID. NO. 131; SEQ. ID. NO. 132; SEQ. ID. NO. 133; SEQ. ID. NO. 135; SEQ. ID. NO. 136; SEQ. ID. NO. 137; SEQ. ID. NO. 138; SEQ. ID. NO. 143; SEQ. ID. NO. 144; SEQ. ID. NO. 145; SEQ. ID. NO. 146; SEQ. ID. NO. 147; SEQ. ID. NO. 148; and amino acid sequences at least 95% identical thereto.

The present invention relates to the preparation and use of a glycolipid fraction from Oscillatoria Planktothrix sp., for the treatment and / or prevention of bacterial gum diseases primarily caused by: Actinobacillum actinomycetemconcomitans, Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola and even more preferably by Porphyromonas gingivalis. Said gum diseases, in particular gingivitis and periodontitis (pyorrhea), are primarily caused by a pro-inflammatory response to components of P. gingivalis, leading to destruction of periodontal tissue, and are often accompanied by osteoclastogenesis (increased number of osteoclasts responsible for destruction of bone tissue), and by chronic infection.

The invention belongs to the technical field of biology and relates to a yolk antibody composition to prevent and treat pathogenesis of Helicobacter pylori, Porphyromonas gingivilis and Streptococcusmutans, a product prepared with the yolk antibody composition and application of the yolk antibody composition. A composition herein to prevent oral sprays for preventing and treating oral diseases caused by pathogenesis of Helicobacter pylori, Porphyromonas gingivilis and Streptococcus mutans comprises, by mass, 2-5 parts of a Streptococcus mutans yolk antibody, 1-5 parts of a Porphyromonas gingivalis yolk antibody and 1-4 parts of a Helicobacter pylori yolk antibody. The Helicobacter pylori, Porphyromonas gingivilis and Streptococcus mutans are prepared into the yolk antibodies to prevent and treat oral diseases; the prepared oral sprays are effective in preventing and treating oral diseases, enhancing antibacterial performance and improving virus resistance, without destroying the oralenvironment or increasing drug resistance of oral bacteria.

The invention discloses a strain of Lactobacillus fermentum capable of preventing and / or treating periodontitis and its application, belonging to the technical field of microorganisms. According to the invention, a strain of Lactobacillus fermentum CCFM1139 is obtained by screening, and the Lactobacillus fermentum CCFM1139 has the effect of relieving periodontitis, which is embodied in that it can inhibit the mixed organisms of Porphyromonas gingivalis, Prevotella intermedia and Fusobacterium nucleatum. The formation of film reduces the amount of biofilm by 52.45%; the content of TNF-α in the periodontitis cell model can be reduced from 131.37pg / mL to 83.31pg / mL, and the content of IL-8 can be reduced from 147.70pg / mL to 121.12 pg / mL; reduced the colonization of Porphyromonas gingivalis and Fusobacterium nucleatum in the oral cavity by 1-2 orders of magnitude; reduced alveolar bone resorption from 1838.0 μm to 805.7 μm.