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Application of cepharanthine in preparation of medicine for treating rheumatoid arthritis

A technology of stephenin and arthritis, which is applied in the field of preparation of drugs for the treatment of rheumatoid arthritis, and can solve the problems of no CEP and other problems

Pending Publication Date: 2022-07-05
WEST CHINA HOSPITAL SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no research on CEP as an antirheumatic drug in animal models of arthritis or clinical application

Method used

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  • Application of cepharanthine in preparation of medicine for treating rheumatoid arthritis
  • Application of cepharanthine in preparation of medicine for treating rheumatoid arthritis
  • Application of cepharanthine in preparation of medicine for treating rheumatoid arthritis

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Embodiment Construction

[0026] The present invention can be better understood from the following examples. However, the contents described in the embodiments are only used to illustrate the present invention, and should not and will not limit the present invention described in detail in the claims.

[0027] (1) Experimental method

[0028] 1. Arthritis modeling and drug delivery

[0029] The solubilized 2 mg / ml bovine type II collagen was repeatedly emulsified with an equal volume of complete (primary immunization) or incomplete (secondary immunization) Freund's adjuvant to prepare an emulsion containing 1 mg / ml bovine type II collagen for preparation. Modeling use. Twenty-one 8-week-old male DBA1 / J mice were randomly divided into three groups: normal control group, model group, and fenugreek treatment group. The mice were injected with 0.1 ml of the above-mentioned emulsion intradermally at 1-2 cm behind the tail root for the first immunization, and the day of injection was recorded as day 0. Tw...

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Abstract

The invention discloses a novel application of Cephaaranthine in treatment of rheumatoid arthritis, and belongs to the field of traditional Chinese medicines. The cepharanthine disclosed by the invention is a bisbenzylisoquinoline compound extracted from a traditional Chinese medicinal material stephania cepharantha, and shows a good treatment effect on a mouse model of inflammatory arthritis induced by collagen; in addition, the cepharanthine has a certain inhibition effect on the cell viability, migration ability and signal transduction pathway of fibroblast-like synovial cells of rheumatoid arthritis patients, which indicates that the cepharanthine has an exact effect of resisting osteoarthritis inflammatory diseases such as rheumatoid arthritis and the like; the compound can be combined with auxiliary materials to prepare anti-rheumatoid arthritis and other inflammatory diseases or be combined with other drugs for treating rheumatoid arthritis.

Description

technical field [0001] The invention relates to a new use of fenugreek, an active component of the Chinese medicinal material, fenugreek, in particular to the use for preparing a drug for treating rheumatoid arthritis, and belongs to the field of traditional Chinese medicine. Background technique [0002] Rheumatoid Arthritis (RA) is a common clinical chronic, autoimmune disease characterized by synovitis. WHO statistics show that about 1% of the world's population suffers from RA. The main pathological changes include synovitis and the destruction of bone and cartilage in the joint, the latter being the direct cause of progressive joint stiffness, deformity, dysfunction and even disability. RA seriously endangers human health and reduces people's quality of life. At present, the treatment of RA is mainly to relieve pain, control inflammation, improve joint function and protect organs. The main measures include drug therapy, immune purification and surgical treatment, amon...

Claims

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Application Information

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IPC IPC(8): A61K31/4741A61K36/59A61P19/02A61P19/06A61P19/08A61P29/00
CPCA61K31/4741A61K36/59A61P19/02A61P19/06A61P19/08A61P29/00
Inventor 鲁晨阳罗玉斌刘毅张秋平魏士雄
Owner WEST CHINA HOSPITAL SICHUAN UNIV
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