Application of compound probiotics in reducing blood fat or relieving obesity

A compound probiotic and obesity technology, applied in the direction of microorganism-based methods, medical preparations containing active ingredients, bacteria, etc., can solve the problem of no combination of different strains, so as to inhibit the production of pathogenic bacteria, reduce blood lipids, The effect of alleviating obesity

Active Publication Date: 2022-07-05
THANKCOME BIOLOGICAL SCI & TECH CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are differences in the suitable growth conditions of different strains, especially to colonize the intestinal tract and achieve good results is not simply achieved by compounding different strains, and considering factors such as cost and control of production process conditions At present, there is a single strain related to the application of obesity or blood lipid reduction, or the compounding of a single strain with other functional ingredients or traditional Chinese medicines, but there is no compounding of different strains for blood lipid reduction or Related reports on application in alleviating obesity

Method used

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  • Application of compound probiotics in reducing blood fat or relieving obesity
  • Application of compound probiotics in reducing blood fat or relieving obesity
  • Application of compound probiotics in reducing blood fat or relieving obesity

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment 1 A kind of preparation of microbial inoculum

[0029] (1) Fermentation of Lactobacillus fermentum

[0030] First, the preserved Lactobacillus fermentum and Bacillus coagulans were respectively activated with MRS liquid medium (Thermo Fisher) at 37°C for 18h to obtain an activated bacterial liquid.

[0031] The Lactobacillus fermentum activated bacterial solution was inoculated into the MRS liquid medium according to the inoculation amount of 3.5%, and anaerobic culture at 37°C for 24 hours to obtain the Lactobacillus fermentum fermentation liquid; the Bacillus coagulans was inoculated into the MRS liquid medium according to the inoculation amount of 4.0% , 37 ℃ aerobic culture for 24h, to obtain Bacillus coagulans fermentation broth.

[0032] The above-mentioned Lactobacillus fermentum fermented liquid and Bacillus coagulans fermented liquid were centrifuged at 10000rpm for 20min, respectively, and the cells were collected and freeze-dried to obtain Lactoba...

Embodiment 2

[0036] Example 2 Effect of compound probiotics on body weight and blood lipid level of normal mice

[0037] BALB / c mice (weight 200±20g) were taken and randomly divided into normal control group, high-fat model group, drug low-dose group (100mL / kg), middle-dose group (200mL / kg), high-dose group (300mL / kg) ) three dose groups, lovastatin 10mg / kg positive control group, 5 mice were randomly selected from each group. Except for the normal control group, the mice were fed with basal feed, and the other groups were fed with high-fat feed (60% of the energy came from fat, purchased from Beijing Keao Xieli Feed Co., Ltd.). The above-mentioned different groups of mice were fed regularly by gavage every day. Normal control The low-dose group, middle-dose group and high-dose group were gavaged with the fermentation liquid of compound probiotics at the required dose once a day for 30 consecutive days, and the body weight of each group was weighed; After 8 hours of incontinence, blood was ...

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Abstract

The invention discloses application of compound probiotics in reducing blood fat or relieving obesity, and belongs to the technical field of microbial fermentation. The invention discloses a compound probiotic which comprises lactobacillus fermentum and bacillus coagulans, and the preservation number of the lactobacillus fermentum is CGMCC (China General Microbiological Culture Collection Center) No.14493; the preservation number of the bacillus coagulans is CCTCC (China Center For Type Culture Collection) NO: M2017813. The microbial preparation is prepared after the lactobacillus fermentum powder and the bacillus coagulans powder are compounded according to different mass ratios, and the obtained microbial agent can effectively achieve the functions of reducing blood fat and relieving obesity and is a product for preventing, relieving or treating blood fat rise related diseases. And a new direction and raw materials are provided for preparing products for relieving obesity.

Description

technical field [0001] The invention relates to the technical field of microbial fermentation, in particular to the application of a compound probiotic in reducing blood lipids or relieving obesity. Background technique [0002] With the improvement of people's living standards, the number of sub-healthy people is increasing, and the number of hyperlipidemia patients and obese people is increasing. Hyperlipidemia often leads to a series of diseases, such as hyperlipidemia, hepatic steatosis, obesity, coronary heart disease, myocardial infarction, etc. The generation of obesity is inseparably related to genetic factors and environmental factors, among which gut microbes are a key factor in regulating human host metabolism and body inflammation. Relevant studies have reported that human dietary habits greatly affect the composition and function of intestinal flora, and are the main factor leading to the occurrence of metabolic diseases. [0003] High blood lipids or obesity ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N1/20A61K35/747A61P3/06A61P1/16A61P3/04A23L33/135C12R1/07C12R1/225A61K35/742
CPCC12N1/20A61K35/747A61K35/742A61P3/06A61P1/16A61P3/04A23L33/135A23V2002/00A23V2400/143A61K2300/00A23V2200/3262A23V2200/332
Inventor 马新喻扬郁雪平
Owner THANKCOME BIOLOGICAL SCI & TECH CO LTD
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