Application of sulforaphane in preparation of medicine for treating rhinitis

A technology of sulforaphane and medicine, applied in the field of medicine, can solve the problems of no verification of the final effect, no explanation of whether the ingredients are effective, no explanation of the main effect, etc.
CN114748464APending Publication Date: 2022-07-15PIONEER HERB IND CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
PIONEER HERB IND CO LTD
Publication Date
2022-07-15

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Abstract

The invention relates to application of sulforaphane in preparation of a medicine for treating rhinitis. The research finds that the sulforaphane has the tendency of relieving rhinitis symptoms in mouse experiments, and further research shows that the sulforaphane can obviously reduce the expression level of inflammatory factors sIgE and his in mice, so that the expression level of inflammatory factors in rhinitis mice is close to that of blank mice, and the sulforaphane shows certain concentration dependence along with increase of dosage. Therefore, the sulforaphane has the curative effect of treating inflammation on the in-vivo inflammatory factor level. Meanwhile, female and male stratified analysis is carried out on each group of mice, it is found that the expression level of sIgE and his in female mice is overall higher than that of male mice, the female mice are more sensitive to inflammation, and in drug effect comparison, the drug effect of the female mice is more obvious. Finally, histological analysis finds that the tissue form of an administration group is superior to that of a control group, so that the sulforaphane can be determined to improve the damaged nasal mucosa epithelial tissue.
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Description

technical field

[0001] The invention belongs to the technical field of medicine, in particular to the application of sulforaphane in the preparation of a medicine for treating rhinitis. Background technique

[0002] Rhinitis is an inflammatory disease of the nasal cavity, which is inflammation of the nasal mucosa due to viruses, bacteria or some other systemic diseases. The main pathological changes of rhinitis are congestion, swelling, exudation, hyperplasia, atrophy or necrosis of nasal mucosa.

[0003] At present, Western medicine mostly uses anti-inflammatory, anti-allergy, pain relief and surgical treatment, which is generally difficult to cure. As we all know, antibiotic treatment often brings some adverse reactions to patients, and surgical treatment brings trauma and pain to patients.

[0004] There are indeed many traditional Chinese medicine treatment methods on the market, and there are many kinds of drugs used in them, but the effects are uneven and not ideal. ...

Claims

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