Pharmaceutical composition for preventing and/or treating cancer

A composition and drug technology, applied in the field of medicine, can solve problems such as poor curative effect, achieve low toxicity, small side effects, and improve pharmacokinetic properties

Active Publication Date: 2022-07-15
XUANZHU BIOPHARMACEUTICAL CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the clinical treatment of breast cancer, the effective rate is generally 30%. Estrogen receptor positive patients have better curative effect (49%), and negative patients have poor curative effect (7%)

Method used

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  • Pharmaceutical composition for preventing and/or treating cancer
  • Pharmaceutical composition for preventing and/or treating cancer
  • Pharmaceutical composition for preventing and/or treating cancer

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0059] Experimental Example 1 In vitro cytological inhibition of the compound of formula (I) of the present invention and tamoxifen alone and in combination active testing sample:

[0060] The compound of formula (I) of the present invention is prepared according to the method of the prior art;

[0061] Tamoxifen: purchased or prepared according to prior art methods.

[0062] The following experimental abbreviations have the following meanings:

[0063]

[0064] Experimental method: BrdU method (BrdU cell proliferation assay kit, PerkinElmer) was used for cell proliferation detection

[0065] 1. Reagent and Compound Preparation

[0066] 1.1 1x lotion preparation:

[0067] Dilute the lotion with a concentration of 25 times of the mother liquor into a 1-fold lotion with ultrapure water.

[0068] 1.2 Preparation of 1x detection antibody solution:

[0069] Dilute the BrdU-Eu detection antibody with a concentration of 200 times of the stock solution into a 1-fold detect...

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PUM

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Abstract

The invention belongs to the technical field of medicines, and particularly relates to a pharmaceutical composition for preventing and / or treating cancers. The invention relates to a medicine composition, in particular to a medicine composition containing a CDK4 / 6 inhibitor compound shown in a formula (I) or pharmaceutically acceptable salt thereof and a second treatment reagent or pharmaceutically acceptable salt thereof, application of the medicine composition in preparation of medicines for preventing and / or treating cancers and a medicine box containing the medicine composition.

Description

technical field [0001] The present invention belongs to the technical field of medicine, and specifically relates to a pharmaceutical composition for preventing and / or treating cancer, especially a compound containing the compound of formula (I) or a pharmaceutically acceptable salt thereof and a second therapeutic agent or a pharmaceutically acceptable salt thereof. Pharmaceutical compositions of salts, and use of said pharmaceutical compositions for preventing and / or treating cancer. Background technique [0002] The functional effects of almost all oncogenes and tumor suppressor genes will eventually converge on the cell cycle, and regulating or blocking the cell cycle is one of the ways to treat tumors. At present, many molecules related to cell cycle regulation have been discovered, among which cyclin-dependent kinases (Cyclin-Dependent-Kinases, CDKs) are the core molecules of the cell cycle regulation network. Among the CDK isoforms involved in the cell cycle, CDK4 / 6 ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/506A61P35/00A61P35/04A61K31/138
CPCA61K31/506A61K31/138A61P35/00A61P35/04A61K2300/00
Inventor 徐艳君孙俊
Owner XUANZHU BIOPHARMACEUTICAL CO LTD
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