Microtextured arterial vascular stent and preparation device and method thereof

Abstract

The invention provides a micro-texture artery blood vessel stent and a preparation device and method thereof. The micro-texture artery blood vessel stent comprises a stent body, and a micro-texture layer is arranged on the inner surface layer of the stent body; or micro-texture layers are arranged on the outer surface layer and the inner surface layer of the stent body; the micro-texture layer is used as a medicine carrying layer. Microtexture layers are processed on the surface layers of the inner and outer cylindrical surfaces of the metal stent substrate by femtosecond laser, serve as a micro-skeleton of a drug-loading layer, form a contact interface with vascular endothelium and arterial blood, realize adjustment of normal and tangential contact stiffness, reduce the circumferential and longitudinal shear stiffness of the stent, and improve the stability of the stent. And stent slippage caused by over-speed degradation of the degradable drug-loading layer is also prevented, and the double constraint problems that the restenosis rate of a metal stent is high after the metal stent is implanted into an artery blood vessel and the long-term thrombus occurrence rate of a drug coating stent for reducing the restenosis rate is high are solved.

Description

technical field [0001] The present invention relates to the technical field of medical arterial vascular stents, in particular to a micro-textured arterial vascular stent and a preparation device and method thereof. In particular, it is preferably related to a femtosecond laser-induced micro-textured arterial vascular stent and a preparation method thereof. Background technique [0002] The development of vascular stents has opened a new era for the treatment of coronary artery disease. Bare metal stent (Bare Metal Stent, BMS) and drug eluting stent (Drug Eluting Stent, DES) implantation has become the mainstream of coronary intervention (Percutaneous Coronary Intervention, PCI). Bare metal stents such as figure 1 shown. In 1987, Schatz et al. launched the first widely used commercial bare metal stent; in 1999, Sousa et al. first implanted a drug-eluting stent into human coronary arteries; it has been put into clinical use in China since 2002. Due to the delayed endothel...

AI Technical Summary

Problems solved by technology

[0007] In view of the above-mentioned related technologies, the inventors believe that the above-mentioned metal stent has a high rate of restenosis after arterial vessel implantation, and the double constraint problem that the drug-coated stent used to reduce the rate of restenosis has a high incidence of long-term thrombosis

Images