Application of NAT10 small-molecule inhibitor in preparation of medicine for treating or preventing depression
A small molecule inhibitor, depression technology, applied in the field of medicine, to achieve the effect of improving depression-like behavior, increasing the percentage of sugar water preference, and reducing immobility time
Pending Publication Date: 2022-08-05
NANHUA UNIV
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Problems solved by technology
[0007] At present, there is no report that remodelin, a small molecule inhibitor of NAT10, can treat depression
Method used
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Embodiment 1
[0029] Example 1 Investigating the effect of NAT10 small molecule inhibitor remodelin on the behavior of LPS-induced depression model mice
[0030] Animals: 30 male C57BL / 6 mice, 2 months old, weighing about 22-25 g. Animals were kept at room temperature (22±2)°C, humidity (45%-65%) and alternating light and dark (12h:12h), with free access to food and water.
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The invention relates to the technical field of medicines, in particular to application of an NAT10 small-molecule inhibitor in preparation of a medicine for treating depression. Lipopolysaccharide (LPS) is injected into a mouse to establish a depression model, an NAT10 small-molecule inhibitor remodelin is injected into the abdominal cavity of the mouse, and the anti-depression effect of the NAT10 small-molecule inhibitor remodelin is evaluated through a tail suspension experiment and a sweet water preference experiment. Results show that the NAT10 small-molecule inhibitor remodelin can obviously reduce the immobility time in a mouse tail suspension experiment, increase the mouse sweet water preference percentage and effectively improve the depression-like behavior of a mouse, and a new way is provided for developing a new anti-depression drug.
Description
technical field [0001] The invention relates to the technical field of medicine, in particular to the application of a NAT10 small molecule inhibitor in the preparation of a medicament for treating or preventing depression. Background technique [0002] Depression is a common mental disorder in clinical practice, and its main clinical manifestations are persistent depression and cognitive dysfunction. With the development of society, people's living pressure is increasing, and depression has become the main obstacle that restricts social development and the happy life of human beings. [0003] The clinical first-line antidepressants mainly include selective serotonin reuptake inhibitors, serotonin and norepinephrine reuptake inhibitors, etc. Unfortunately, although the efficacy of traditional antidepressants is worthy of recognition, they generally have the disadvantages of slow onset, weak efficacy, and short duration of action, and only half of the patients have a good re...
Claims
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Login to View More IPC IPC(8): A61K31/426A61P25/24
CPCA61K31/426A61P25/24
Inventor 曹文宇许晓帆徐杨时萌萌郭东铭
Owner NANHUA UNIV
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