Magnetic particle preparation process

Abstract

The invention discloses a magnetic particle preparation process, and belongs to the technical field of magnetic particle preparation. The method comprises the following steps: extracting silicate and carbonate in sodium hydroxide, standing the extracted solution for 20 minutes, screening out impurities in the solution, pouring the screened solution into cooling equipment for cooling, standing the standing extracting solution, cooling and standing, magnetically stirring in a magnetic stirrer, mixing ferric chloride and polyacrylic acid, putting the mixed substance into a closed vessel, and uniformly stirring. Filling the inner cavity of the closed vessel with nitrogen, increasing the temperature of the inner cavity of the closed vessel while filling the nitrogen, magnetically stirring the mixed substance, heating to 220 DEG C, treating, pouring a sodium hydroxide solution into a mixed solution of ferric chloride and polyacrylic acid, observing whether the color change of the solution meets the requirement, and packaging and leaving a factory. In the preparation process, the device is filled with nitrogen, the chemical property of the nitrogen is inactive, and the situation that the preparation result does not reach the preset standard due to the fact that the nitrogen reacts with external gas in the preparation process can be avoided.

Description

technical field [0001] The present invention relates to the technical field of magnetic particle preparation, and more particularly, to a magnetic particle preparation process. Background technique [0002] Magnetic particles refer to colloidal composite materials that can be uniformly dispersed in a certain base liquid. Because of its superparamagnetic properties, high specific surface area, and functional groups that can be modified. Therefore, antigens / antibodies, enzymes, nucleic acids / oligonucleotides, small molecule drugs, etc. are immobilized on its surface. In addition to surgical operations, chemical drugs, biological toxins and radionuclides are mainly used, but the selectivity of drug treatment is low. , large toxic and side effects, anti-tumor drugs quickly disappear from the site of action and other defects. Polymer-coated magnetic particles for in vivo therapy have become a new technology for drug-targeted release. In this technology, anticancer drugs are co...

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Problems solved by technology

[0007] The purpose of the present invention is to provide a magnetic particle preparation process, which cannot be filled with nitrogen gas in the device during the preparation process. The chemical properties of nitrogen gas are relatively inactive, which can avoid the reaction with the external gas during the preparation process, resulting in the failure of the preparation result. The problem of preset standards occurs to solve the problems raised in the above background technology

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