Artificial nerve conduit with PLGA (poly (lactic-co-glycolic acid)) and acellular extracellular matrix as substrates as well as preparation method and device of artificial nerve conduit

Abstract

The invention provides an artificial nerve conduit with PLGA (poly (lactic-co-glycolic acid)) and acellular extracellular matrix as substrates, and a preparation method and device, and belongs to the technical field of biological materials or biological manufacturing or peripheral nerve repair or tissue engineering, and the preparation method comprises the following steps: preparing a nerve conduit; preparing a decellularized kidney; preparing decellularized nerves; preparing the decellularized muscle; and preparing the composite catheter containing the decellularized tissue. According to the embodiment of the invention, the artificial nerve conduit which is high enough in strength and has promoting significance on nerve regeneration can be prepared, meanwhile, the recovery time of a patient suffering from peripheral nerve injury can be shortened, the prognosis of the patient is further improved, and the life quality of the patient is improved.

Description

technical field [0001] The invention belongs to the technical field of biomaterials or biomanufacturing or peripheral nerve repair or tissue engineering, in particular to an artificial nerve conduit based on PLGA and decellularized matrix, a preparation method and a device. Background technique [0002] At present, the ideal nerve conduit should have the following characteristics: it can provide sufficient mechanical support strength for nerve fibers; it can guide the movement of regenerated axons from the proximal end to the distal nerve trunk; it can promote the accumulation of nerve stimulating factors, thereby guiding nerve regeneration; Reduces the formation of scar tissue. However, it is difficult for the nerve conduits prepared by existing materials and methods to satisfy these conditions at the same time. The conduits prepared from materials with good biocompatibility are often not strong enough, and the conduits with sufficient strength are often difficult to contai...

AI Technical Summary

Problems solved by technology

However, it is difficult for the nerve conduits prepared by existing materials and methods to meet these conditions well at the same time. The conduits made of materials with good biocompatibility are often not strong enough, and the conduits with sufficient strength are often difficult to contain factors that promote nerve growth.

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