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Mixed snuff prepn. for reducing side effect of Apomorphinum

A technology for nasal administration preparations and side effects, which is applied in the field of new compound preparations and can solve problems such as abnormal taste and dizziness

Inactive Publication Date: 2005-06-22
ZHEJIANG ACAD OF MEDICAL SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, some patients may experience side effects such as nausea, vomiting, dizziness and abnormal taste

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Apomorphine Hydrochloride 1.4g

[0017] Menthol 0.7g

[0018] Hydroxypropyl beta cyclodextrin 10g

[0019] Sodium metabisulfite 0.3g

[0020] EDTA-2Na 0.05g

[0021] Distilled water to 100ml

[0022] The effect of menthol on the incidence of emesis after intranasal administration of apomorphine was studied in dogs. The 8 dogs were divided into two groups, 4 dogs in each group, half male and half male. The first group received a menthol-containing formulation and the second a menthol-free formulation. The other ingredients of the two preparations are the same, and 0.2ml is instilled into the nasal cavity of each dog. Results None of the rats in the first group vomited, but two of the rats in the second group vomited.

[0023] Dogs are known to be suitable models for studying the emetic response to apomorphine. And dogs are 5-10 times more sensitive to apomorphine-induced vomiting than humans. If the apomorphine preparation does not cause vomiting after being use...

Embodiment 2

[0025] Apomorphine Hydrochloride 2.8g

[0026] Licorice 1.5g

[0027] ice flakes 1.5g

[0028] The above-mentioned medicines are crushed separately, passed through a 120-mesh sieve, and mixed evenly for nasal inhalation.

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Abstract

An apomorphine compound nasal administration preparation for treating Parkinson's syndrome, male erectile dysfunction and female sexual dysfunction. The side effects such as nausea, vomiting, dizziness and abnormal taste during the treatment of apomorphine can be eliminated or reduced by using the compound preparation of menthol, peppermint oil or borneol with antiemetic effect. Aromatic substances are added to make the nasal cavity have a fragrance and a comfortable feeling after administration. Add natural or synthetic polymer compounds to the liquid preparation to delay the residence time of the drug in the nasal cavity. The preparation has the advantages of delivering medicine to the brain, and is convenient to use, safe, effective and good in compliance.

Description

technical field [0001] The invention is a novel compound preparation, especially a compound nasal administration preparation for treating Parkinson's syndrome, male erectile dysfunction and female sexual dysfunction and reducing the side effects of apomorphine. Background technique [0002] Apomorphine is a dopamine receptor agonist that acts on the central nervous system, and its action site is in the hypothalamus. Apomorphine has a good effect in the treatment of Parkinson's syndrome, and there have been extensive studies and reports on the treatment of impotence or sexual dysfunction. U.S. Patent No. 5,888,534 and No. 5,994,363 etc. have been disclosed for improving male erectile dysfunction. US Patent No. 5,945,117 also discloses the use of apomorphine to improve female sexual dysfunction. WO 99 / 27905 discloses the treatment of erectile dysfunction with nasal administration of apomorphine. Sublingual apomorphine tablets (usually containing 2.5-...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/485A61P15/08A61P25/16
Inventor 陈国神蒋新国张望刚陆伟郑高利陈钧
Owner ZHEJIANG ACAD OF MEDICAL SCI