Rifapentine or Rifampicin microemulsion and suspension perfusate and injection and their preparation
A technology of rifapentine and rifampicin, which is applied in the field of broad-spectrum killing Mycobacterium tuberculosis antibiotic drug microemulsion solution, can solve the problem that there are not many effective treatment methods for refractory tuberculosis, and reduce economic burden and pain. , the effect of shortening the treatment period
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Embodiment 1
[0024] Rifapentine or rifampicin microemulsion solution formula (weight percentage, following formula is the same):
[0025] Rifapentine or rifampicin 3.5
[0026] Lauroyl diethanolamine 8
[0027] Distilled water 88.5.
[0028] Preparation:
[0029] Accurately weigh rifapentine or rifampicin, lauroyl diethanolamine, place in a round-bottomed flask, add chloroform and shake, so that each component is fully dissolved, and a red transparent solution is formed. Water bath at 50°C, vacuumize, and distill to remove the solvent, so that the drug and emulsifier form a transparent red film on the bottle wall. Add a little distilled water to wet the film, stir to dissolve the film, then add distilled water to become a transparent solution. Pour out the solution, wash the flask several times with the remaining distilled water, combine the obtained solutions, and ultrasonically vibrate or grind to obtain a nearly transparent red solution, which is the rifapentine or rifampicin microe...
Embodiment 2
[0031] Rifapentine or rifampicin compound drug microemulsion formula:
[0032] Rifapentine or rifampicin 3.5
[0033] Ciprofloxacin 2
[0034] Lauroyl diethanolamine 8
[0035] Lidocaine 0.05
[0036] Distilled water 86.45.
[0037] Method of preparation:
[0038] Accurately weigh rifapentine or rifampicin, ciprofloxacin, lauroyl diethanolamine, and lidocaine and place them in a reactor, add chloroform and absolute ethanol, and oscillate to fully dissolve each component, forming a red transparent solution .
[0039] Water bath at 50°C, vacuumize, and distill off the solvent, so that the drug and emulsifier form a thin film on the wall of the vessel.
[0040] Add a little distilled water to wet the film, stir vigorously to dissolve the film, then add distilled water to become a translucent solution.
[0041] Pour out the solution, wash the reactor several times with the remaining distilled water, combine the obtained solutions, and ultrasonically oscillate or grind to ob...
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