Cefixime pharmaceutical composition for injection

A technology of drug compound and cefixime, which is used in drug delivery, antibacterial drugs, pharmaceutical formulations, etc., can solve the problems of low bioavailability of oral preparations, gastrointestinal adverse reactions, and the inability of cefixime to be directly made into injections, etc. , to achieve the effect of low cost, low toxicity, and reduced toxic and side effects

Inactive Publication Date: 2006-06-21
余安国
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The present invention aims to solve the problem that cefixime cannot be directly made into injection, its oral preparation has low bioavailability, and there are a series of gastrointestinal adverse reactions, and provides a cefixime preparation that can be used for injection, which can fully exert the The antibacterial effect of cefixime overcomes the defects caused by oral preparations of cefixime

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Embodiment 1: preparation example

[0021] prescription:

[0022] Raw material name dosage

[0023] Cefixime 100g

[0024] L-Arginine 100g

[0025] Make 1000 pieces

[0026] Preparation Process:

[0027] Under a sterile environment, fully mix 100 g of cefixime refined product (refined with methanol, aseptically washed and dried with 75% ethanol) and 100 g of L-arginine sterile powder in a sterile aluminum bucket, and pack into Pack of 1000, closed with butyl rubber stoppers.

Embodiment 2

[0028] Embodiment 2: preparation example

[0029] prescription:

[0030] Raw material name dosage

[0031] Cefixime 100g

[0032] Anhydrous sodium carbonate 33.3g

[0033] Make 1000 pieces

[0034] Preparation Process:

[0035] Under a sterile environment, 100 g of cefixime refined product (refined with methanol, aseptically washed with 75% ethanol, and dried) and 33.3 g of anhydrous sodium carbonate sterile powder are fully mixed in a sterile aluminum bucket, and packed into Pack of 1000, closed with butyl rubber stoppers.

Embodiment 3

[0037] weight ratio

[0038] It can be seen from the above table that the cefixime complex prepared by cefixime and L-arginine at a weight ratio of 1.5:1 has good solubility in water, and the pH value is moderate, and the relevant substances are qualified.

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PUM

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Abstract

The invention discloses a drug compound of cefixime for injection, which is prepared by fully mixing the active component cefixime and a cosolvent in a weight ratio of 1 to 15:1 under a sterile environment. The cosolvent is selected from inorganic or organic acid salts of basic amino acids, alkali metals or alkaline earth metals. The preparation of the present invention has good stability, low cost, high water solubility, and is more conducive to human body absorption. The drug effect is fast and long-lasting. The utilization is high, and the toxicity and side effects are significantly lower than that of cefixime itself.

Description

Technical field: [0001] The invention relates to a drug compound of cephalosporin antibiotics, in particular to the third-generation cephalosporin antibiotic cefixime as an active ingredient, basic amino acids, inorganic or organic acid salts of alkali metals or alkaline earth metals as auxiliary components. Solvent, prepared drug compound for injection. Background technique: [0002] The antibiotic cefixime (Cefixime, C 16 h 15 N 5 o 7 S 2 ) is a third-generation oral cephalosporin antibiotic. Cefixime has a strong affinity for target enzymes and high stability for β-lactamase. Cefixime has a broad-spectrum antibacterial effect on Gram-positive and Gram-negative bacteria, especially influenzae (such as: Streptococcus pneumoniae, Streptococcus epidermidis), pneumococcus and Gram-negative bacteria among Gram-positive bacteria Haemophilus influenzae, Moraxella, Catarella, Proteus mirabilis, Neisseria gonorrhoeae, Branhamella catarrhalis, Escherichia coli, Klebsiella, Se...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/546A61K9/08A61P31/04
Inventor 余安国林国华唐朝云莫兆明李莎
Owner 余安国
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