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Haw leaf injection for treating cardiovascular disease

An injection, hawthorn leaf technology, applied in the field of injection medicine, can solve the problems of slow onset, weak drug effect, insignificant treatment effect, etc., and can reduce coronary resistance, increase cardiac output, and increase coronary blood flow. Effect

Inactive Publication Date: 2006-06-21
SHINEWAY PHARMA GRP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It has the disadvantages of weak drug effect, slow onset, and insignificant therapeutic effect

Method used

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  • Haw leaf injection for treating cardiovascular disease
  • Haw leaf injection for treating cardiovascular disease
  • Haw leaf injection for treating cardiovascular disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0084] Example 1: Preparation of Hawthorn Leaf Injection for the Treatment of Cardiovascular Diseases

[0085] Take 40kg of hawthorn leaves, add 8 times the amount of 50% ethanol (60°C) and soak for three times, each time for 4 hours, filter, combine the filtrates, recover ethanol, concentrate to a relative density of 1.12-1.14 (50°C), add 160kg of water , heated to boiling, let cool, refrigerated for 24 hours, absorbed the supernatant, filtered the lower layer, combined the filtrate and the supernatant, put it on a macroporous adsorption resin column, and eluted it with distilled water and 20% ethanol solution respectively, until α-naphthalene Phenol concentrated sulfuric acid reaction was negative. Discard the water wash and 20% ethanol eluate; use 40% ethanol to elute, collect the 40% ethanol eluate until the hydrochloric acid-magnesium powder reaction is negative, recover ethanol, concentrate to a relative density of 1.02-1.04 (50°C ), let it cool, put in a separatory fun...

Embodiment 2

[0090] Preparation of Hawthorn Leaf Powder Injection for Treating Cardiovascular Diseases

[0091] According to the method for preparing the hawthorn leaf extract for injection in Example 1, 1000 g of the hawthorn leaf extract was prepared.

[0092] Get 1000g of the hawthorn leaf extract and refine it into a powder for injection.

[0093] 0.25g each.

[0094] For content determination, add 250ml of distilled water to each tube, and each 1ml contains 10.0mg of total flavonoids calculated as vitexin rhamnoside.

[0095] Each 1ml contains vitexin rhamnoside (C 27 h 30 o 14 ) and vitexin glucoside are 50% of the total flavonoids.

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Abstract

The invention discloses a hawthorn leaf injection for treating cardiovascular diseases, which is prepared from hawthorn leaf extract and a solvent for injection, and the solution contains total flavonoids in an effective therapeutic amount. The hawthorn leaf extract is prepared by the following method: a. take hawthorn leaves, add 40-60% ethanol to extract, filter, recover ethanol, concentrate to a relative density of 1.12-1.14, dilute with water, and refrigerate for 12-24 hours. Aspirate the supernatant, filter the lower layer, combine the filtrate and the supernatant, and elute until the reaction of concentrated sulfuric acid of α-naphthol is negative; b. Collect the ethanol eluate until the reaction of magnesium hydrochloride powder is negative, recover the ethanol, concentrate, Extract with ethyl acetate, recover ethyl acetate from the extract and concentrate to dryness to obtain extract I; extract the water layer with n-butanol and concentrate to dry to obtain extract II; the present invention has effects on the ejection ability and oxygen metabolism of the heart It has obvious improvement effect, can significantly increase cardiac output and stroke volume, reduce arterial blood oxygen content, increase venous blood oxygen content, reduce myocardial oxygen consumption and myocardial oxygen utilization rate, and improve myocardial blood and oxygen supply.

Description

technical field [0001] The invention relates to pharmaceutical preparations, in particular to injection medicine prepared from plant extracts. Background technique [0002] Hawthorn leaves are the leaves of the Rosaceae plant Hawthorn. Modern studies have shown that hawthorn leaves contain a variety of physiologically active ingredients. The total flavonoids composed of vitexin rhamnoside and vitexin glucoside contained in the hawthorn leaf extract can significantly increase coronary blood flow, expand coronary blood vessels, and reduce coronary resistance. When different etiologies cause myocardial ischemia or myocardial infarction, it can improve the pathological manifestations of myocardial ischemia and myocardial infarction, reduce the degree of myocardial ischemia, and reduce the extent of myocardial infarction. Hawthorn leaf extract has been used in the prevention and treatment of cardiovascular diseases. For example, Yixindone Tablets recorded in "Pharmacopoeia of t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/734A61K127/00A61P9/10
Inventor 李振江
Owner SHINEWAY PHARMA GRP LTD
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