Jinyukang-oral medicine for curing depression

Abstract

The oral medicine for treating depression, named Jinyukang, is prepared with extractive of the effective part of Hypericum perforatum. It features that total content of hypericin and pseudohypericin of 0.15-48%, rutin content of 2.3-4%, general flavone content of 50-90% and hyperforin content of 2-46%. The oral preparation includes tablet, capsule, medicine powder and oral liquid. The extractive is extracted directly from Hypericum perforatum or refining coarse extractive of Hypericum perforatum.

Description

technical field [0001] The invention relates to an oral medicine for treating depression—Jinyukang, which belongs to the technical field of international patent classification drug preparation A61K35 / 78. Background technique [0002] Depression is one of the major diseases in today's society. With the intensification of various stress factors, such as the accelerated pace of people's life, the aging population, and the intensified social competition, depression has become a common disease in modern society, with a high incidence and its incidence is increasing rapidly. According to statistics, the world's depressed patients account for 3% to 5% of the world's population. [0003] With the popularization of depression and the improvement of people's living standards and the improvement of the quality of life requirements, depression has attracted more and more people's attention. The medical expenses for the treatment of depression have also increased shar...

AI Technical Summary

Problems solved by technology

However, due to its anticholinergic effect and toxicity to the heart, it is difficult for some patients and the elderly to accept it.

Tetracyclic antidepressants have been partially improved on the basis of TCA, but the effect is not very satisfactory

Several non-tricyclic antidepressants appeared in the 1970s, such as maprotiline and miraminoserin, but the toxic and side effects have not been completely overcome; 2. Selective serotonin reuptake inhibitors, typical drugs include fluoxetine Sertraline, Paroxetine, Sertraline, Siptidelan, etc.

Its pharmacological feature is to specifically block the reabsorption of serotonin, and its affinity to other neurotransmitter receptors in the brain is very low, which is less toxic than tricyclics, but it still has certain side effects

3. Monoamine oxidase inhibitors are effective drugs for the treatment of depression discovered in the 1950s. These drugs are non-selective inhibitors with many side effects and high toxicity. Cyclopropylamine, etc., are used with extreme caution in clinical practice

However, in some patents or preparations, in the preparation process, only the content of total hypericin (not including hypericin) or the content of hypericin is considered, and the requirements for the content of flavonoids are not clear enough