Jinyukang-oral medicine for curing depression

A depression, oral liquid technology, applied in the field of oral medicine, can solve the problems of high toxicity, low affinity, only considering hypericin

Inactive Publication Date: 2003-04-09
BEIJING WBL PEKING UNIV BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to its anticholinergic effect and toxicity to the heart, it is difficult for some patients and the elderly to accept it.
Tetracyclic antidepressants have been partially improved on the basis of TCA, but the effect is not very satisfactory
Several non-tricyclic antidepressants appeared in the 1970s, such as maprotiline and miraminoserin, but the toxic and side effects have not been completely overcome; 2. Selective serotonin reuptake inhibitors, typical drugs include fluoxetine Sertraline, Paroxetine, Sertraline, Siptidelan, etc.
Its pharmacological feature is to specifically block the reabsorption of serotonin, and its affinity to other neurotransmitter receptors in the brain is very low, which is less toxic than tricyclics, but it still has certain side effects
3. Monoamine oxidase inhibitors are effective drugs for the treatment of depression discovered in the 1950s. These drugs are non-selective inhibitors with many side effects and high toxicity. Cyclopropylamine, etc., are used with extreme caution in clinical practice
However, in some patents or preparations, in the preparation process, only the content of total hypericin (not including hypericin) or the content of hypericin is considered, and the requirements for the content of flavonoids are not clear enough

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0030]Hypericum perforatum was extracted three times. For the first time, add 10 times the amount of 55% ethanol, soak at room temperature for 12 hours, reflux for 2 hours, filter, add 6 times the amount of 55% ethanol for the second time, reflux for 1 hour, filter, and add 6 times the amount for the third time. Double the amount of 55% ethanol to reflux for 1 hour, filter, combine the filtrates three times, recover the ethanol, concentrate to a relative density of 1.35 (50-60°C), dry under reduced pressure (50-60°C), and pulverize through a 80-100 mesh sieve. Hypericum perforatum crude extract.

[0031] The crude extract of Hypericum perforatum was extracted twice, firstly add 20 times of 15% ethanol at 60°C and stir for 30 minutes, then centrifuge the extract (3000 rpm) for 25 minutes, add 10 times of 15% ethanol for the second time, 60 Stir and extract at ℃ for 20 minutes, centrifuge for 25 minutes, combine the secondary supernatant, mix well, pass through the D-101 macropo...

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PUM

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Abstract

The oral medicine for treating depression, named Jinyukang, is prepared with extractive of the effective part of Hypericum perforatum. It features that total content of hypericin and pseudohypericin of 0.15-48%, rutin content of 2.3-4%, general flavone content of 50-90% and hyperforin content of 2-46%. The oral preparation includes tablet, capsule, medicine powder and oral liquid. The extractive is extracted directly from Hypericum perforatum or refining coarse extractive of Hypericum perforatum.

Description

technical field [0001] The invention relates to an oral medicine for treating depression—Jinyukang, which belongs to the technical field of international patent classification drug preparation A61K35 / 78. Background technique [0002] Depression is one of the major diseases in today's society. With the intensification of various stress factors, such as the accelerated pace of people's life, the aging population, and the intensification of social competition, depression has become a common disease with a high incidence in modern society. Its incidence is rapidly increasing. According to statistics, the world's depressed patients account for 3% to 5% of the world's population. [0003] With the popularization of depression and the improvement of people's living standards and the improvement of the quality of life requirements, depression has attracted more and more people's attention. The medical expenses for the treatment of depression have also increased sha...

Claims

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Application Information

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IPC IPC(8): A61P25/24
Inventor 张茂良段震文郭树仁何大林
Owner BEIJING WBL PEKING UNIV BIOTECH
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