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Rhodiola sacra soft capsule and its preparation

A technology of rhodiola and holy land, applied in the field of medicine, can solve the problems of restricting the application of holy land rhodiola, unable to meet the control of disease, and effectively control symptoms, etc., to achieve the effect of promoting further application, quick onset, and exact active ingredients

Inactive Publication Date: 2006-08-09
SICHUAN HENGKANG DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] Currently, only tablets, hard capsules, oral liquids, and granules are clinically used as the main raw material of Rhodiola sacrum, all of which are crude extract preparations of Rhodiola sacrum, containing excipients. The disintegration time is long, the onset of effect is slow, and the medication cycle is long. It cannot effectively control the symptoms in a short period of time, and cannot meet the clinical needs of controlling the disease in a short period of time, thus greatly limiting the further clinical application of Rhodiola rosea.

Method used

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  • Rhodiola sacra soft capsule and its preparation

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0036] Experimental example 1 Research on the extraction method of the active ingredients of Rhodiola rosea (water extraction and alcohol precipitation method):

[0037] (1) Orthogonal experiments were used to investigate the yield of the Holy Land Rhodiola extract under different water additions, different decoction times, and different decoction times, and the best water extraction conditions were obtained by adding 8 times the amount water, decocting 3 times, each decocting time is 3 hours.

[0038] (2) Orthogonal experiments were also used to investigate the conditions of ethanol precipitation, and the precipitation amount of ethanol with different concentrations such as 75%, 80%, and 85% was investigated respectively. Combined with the actual situation of process production, the best alcohol precipitation condition is 80% ethanol precipitation for 48 hours. The filtered sediment mainly contains starch, tannin, vegetable protein and rhodiola rosea polysaccharide.

[0039...

experiment example 2

[0041] Experimental example 2 Research on the extraction method of the active ingredients of Rhodiola of Holy Land (ethanol reflux method + water extraction method):

[0042] (1) investigate conditional factors such as the consumption, time, times of ethanol reflux extraction respectively with the method of orthogonal test, according to the height of ointment yield under different conditions, obtain the best reflux condition and be: ethanol reflux extracts 3 times, the second Add 10 times the amount of 75% ethanol once to reflux for 3 hours, and add 8 times the amount of 80% ethanol for the second and third times to reflux for 2 hours. The reflux liquid obtained under this condition is mainly composed of glycosides and total flavonoids, and contains a small amount of polysaccharides. Adjust the alcohol content of the reflux extract so that substances such as polysaccharides can be precipitated as much as possible.

[0043] (2) The residual polysaccharides in the dregs left by...

experiment example 3

[0046] Experimental example 3 Pharmacodynamic research of soft capsules of the present invention

[0047] The clinical dosage of Shengdi Rhodiola Soft Capsules is 1-2 capsules / time, 3 times / day, the soft capsule contains 0.25g / capsule of solid content, and the maximum clinical dosage is 3.0g / 60kg (equivalent to 0.05 / kg). The animal doses are 1g / kg, 0.5g / kg, 0.25g / kg respectively, equivalent to 20 times, 10 times and 5 times of the clinical dose.

[0048] 1. Administration method: intragastric administration is consistent with the clinical administration route, once a day for 7 consecutive days, and the test is carried out 60 minutes after the last administration.

[0049] 2. Comparison:

[0050] 1. Blank control: equal volume of normal saline;

[0051] 2. Positive control: "Nuodikang" capsule (Tibet Nuodikang Pharmaceutical Co., Ltd.), the dose is equivalent to 10 times the clinical dose.

[0052] 3. Statistical method: T test or X 2 test.

[0053] 4. Methods and results:...

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Abstract

The invention provides a Rhodiola sacra effective position extract and its preparation, which is in the form of Rhodiola sacra soft capsule, the effective position extract comprises salidroside, flavones and polysaccharides.

Description

technical field [0001] The invention relates to a traditional Chinese medicine soft capsule preparation and a preparation method thereof, in particular to a holy land rhodiola soft capsule preparation and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] Rhodiola (RHODIOLA) is a plant of the genus Rhodiola in the Sedum family, and it is called "Suromabu" in Tibetan. It is a perennial plant or shrub. Because it contains red pigment, its roots and rhizomes are red, and its infusion is also red. It is also a sedum plant, so it is named Rhodiola rosea. Distributed in the Far East of the former Soviet Union and the alpine regions of Northeast, Northwest, and Southwest China, with an altitude of about 1500-4000 meters. There are more than 90 kinds of Rhodiola in the world, and there are many kinds of Rhodiola in my country, and there are 72 kinds of wild materials. Rhodiola is slightly fragrant, bitter, astringent, and cold...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K36/41A61P35/00A61P5/00A61P39/02A61P43/00A61K31/715
Inventor 阙文彬
Owner SICHUAN HENGKANG DEV
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