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Glue for medical use

A composite stabilizer, n-butyl cyanoacrylate technology, applied in application, medical science, surgery, etc., can solve the problems of human body irritation, imperfect formula, unsatisfactory curing speed and so on

Inactive Publication Date: 2007-01-31
BEIJING COMPONT MEDICAL DEVICES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing medical glue, because the formula is not perfect, and generally all use SO 2 As a polymerization inhibitor, it is difficult to control the dosage, which makes the molded product unstable, the curing speed is not ideal when used, the adhesive strength is not enough, and it is prone to whitening when used, which is very irritating to the human body and makes people feel burning.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Composition: 97 grams of n-butyl cyanoacrylate, 6 grams of dimethyl sebacate, 10.3 mg of hydroquinone, 46.4 mg of compound stabilizer p-toluenesulfonic acid and 5 mg of dioctyl phthalate; Measure the above-mentioned substances, and mix them uniformly to obtain the product medical glue of the present invention. The various components used are commercially available.

[0015] The product of embodiment one is carried out performance test:

[0016] Cure speed test:

[0017] Method: Add 50ml of 0.3g / L sodium bicarbonate solution to a plate with a diameter of 90mm, absorb the medical glue with a dropper, drop a drop at a point 5cm above the liquid surface, and record the curing time of the glue.

[0018] Data: The curing time of the medical glue in this case is 8s.

[0019] Adhesive strength:

[0020] Method: Use pig, sheep or rabbit skin as the test leather, with a thickness of 1mm-1.5mm and a length of 50mm×10mm. Scrub the front surface of the leather test piece with p...

Embodiment 2 Embodiment 6

[0026] The following Table 1 is used for the composition and prepared according to the method of Example 1.

[0027] components

Embodiment two

Embodiment Three

Embodiment four

Embodiment five

Embodiment six

n-Butyl cyanoacrylate g

94

95

94

96

97

Dimethyl sebacate g

3

4

5

2

5

Hydroquinone mg

9.7

39.6

29.7

49

20.4

p-toluenesulfonic acid mg

26.8

9.9

52.9

47

79.2

Dioctyl phthalate mg

2.3

-

5.9

2.5

2.4

performance test results

Curing speed (s)

8

8

8

12

10

Adhesive strength (N)

10

10

10

10

10

Stabilization time (Y)

＞2

＞2

＞2

＞2

＞2

[0028] Compared with the existing similar products, the products of the above embodiments have moderate curing speed, long...

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PUM

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Abstract

The composition of medical adhesive includes (by weight portion) 940-970 portions of butyl cyanoacrylate, 30-60 portions of dimethyl sebacate, 0.1-0.5 portions of p-benzenediol and 0.1-0.8 portion of compound stabilizing agent, in which the described butyl cyanoacrylate is n-butyl alpha-cyanoacrylate, and the described compound stabilizing agent is made from toluene-p-sulfonic acid and dioctyl (0-) phthalate according to 90-100:0-10 weight portion. Its solidifying speed is moderate, adhesive strength is high, it is applicable to various wounds and incision of operation instead of suture needle and silk suture.

Description

technical field [0001] The invention relates to a medical polymer material, in particular to a medical adhesive. Background technique [0002] Medical adhesives are mainly used in various surgical operations such as various trauma wounds, cosmetic surgery, family planning, etc. It has the functions of fast bonding to human biological tissues, promoting wound healing, etc., and can partially replace wound sutures. Existing medical glue, because the formula is not perfect, and generally all use SO 2 As a polymerization inhibitor, it is difficult to control the dosage, which makes the molded product unstable, the curing speed is not ideal when used, the adhesive strength is not enough, and it is prone to whitening when used, which is very irritating to the human body and makes people feel burning. Contents of the invention [0003] The purpose of the present invention is to provide a medical adhesive with moderate curing speed, high bonding strength, low exothermic heat duri...

Claims

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Application Information

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IPC IPC(8): A61L24/06C08L35/04
Inventor 沈伟
Owner BEIJING COMPONT MEDICAL DEVICES
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