Drop pills prepared from andrographolide sulfonated compounds and preparation method thereof

A technology of andrographolide and sulfonate, which is applied in the field of drop pills prepared from andrographolide sulfonate and its preparation, can solve problems that are not conducive to improving the ability of patients to seek medical treatment, the bioavailability of the first-pass effect of the liver and intestines, and the health of staff. Harm and other issues, to achieve the effect of improving bioavailability, stable properties, and convenient storage

Inactive Publication Date: 2007-02-21
北京博智绿洲医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] In addition, the oral preparations of most drugs, especially the oral preparations of traditional Chinese medicine, have problems such as long dissolution time, low dissolution rate, poor absorption, hepatic and intestinal first-pass effect and low bioavailability after taking, which affect the quality of the drug. Efficacy, also directly affects the therapeutic effect Conventional oral dosage forms, such as tablets, capsules, etc.
In addition, due to the granulation process in the preparation process, large dust pollution will be generated, which will cause harm to the health of the staff to a certain extent, and will also cause certain pollution to the environment.
Furthermore, the production process of conventional oral preparations is complicated and the production cost is high, so that the cost of medication for patients is also increased, which is not conducive to improving the ability of patients to seek medical treatment, and is also not conducive to improving the overall health level of society.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0036] The preparation method of Xiyanping dripping pills of the present invention will be further described with several groups of specific examples.

[0037] Group 1: Tests with a single matrix

[0038] 1. Andrographolide sulfonate;

[0039] 2. Substrate: polyethylene glycol (1000～20000), polyoxyl 40 stearate, beta cyclodextrin, poloxamer, sodium carboxymethyl starch, sodium lauryl sulfate, stearic acid, sodium stearate, glycerin gelatin, shellac, etc. pharmaceutical carrier;

[0040] 3. Proportion—take g or kg as the unit, by weight, drug:substrate=1:1~1:9;

[0041] 4. Then prepare according to the process of [Preparation Method] 4-7, that is, Xiyanping dripping pills of various specifications can be prepared.

[0042] [test results]

[0043] Experiment 1: In order to observe the difference in quality of Xiyanping dripping pills prepared when the ratio of andrographolide sulfonate and different bases was 1:1, the ratio of andrographolide sulfonate was divided into wit...

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PUM

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Abstract

A dripping pill of the Chinese medicine Xiyanping for treating bronchitis, tonsillitis and bacterial dysentery and its preparing process are disclosed.

Description

technical field [0001] The present invention relates to a kind of medicinal composition that can clear heat and detoxify, relieve cough and dysentery, and is used for the treatment of bronchitis, tonsillitis, bacillary dysentery, etc. Oral drop pill preparation of a kind of pharmaceutical composition formed by drug route. Background technique [0002] According to the formula and extraction process given in the national drug standard WS-10862 (ZD-0863)-2002, Xiyanping injection is a kind of liquid with clearing away heat and detoxification; Injection preparations for the treatment of infections, bronchial pneumonia, viral pneumonia, suppurative diseases, gynecological inflammation and postoperative fever have been clinically verified for many years, with stable quality and definite curative effect. They are commonly used in clinics and families to treat the above diseases. Pharmaceutical preparations. [0003] The following are the formula and extraction process of Xiyanpi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/365A61K9/20A61P11/00A61P11/04A61P31/04
CPCY02A50/30
Inventor 曲韵智
Owner 北京博智绿洲医药科技有限公司
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