Nutritional preparation comprising ribose and folic acid and medical use thereof

Abstract

Trauma, surgery, inflammation, subfertility, lactation problems, gut disorders, infant nutrition, cancer, arthritis and other joint problems, vascular problems and cardio-or cerebro vascular problems, ischaemia, aging, impaired immune function, burns, sepsis, malnutrition, problems with liver or kidneys, malaria, cystic fibrosis, migraine, neurological problems, respiratory infections, improvement of sports results, muscle soreness, drug intoxication and pain can be treated with a nutritional composition containing effective amounts of ribose and folic acid, optionally combined with other components such as niacin, histidine, glutamine, orotate, vitamin B6 and other components.

Description

[0001] The present invention relates to nutritional, pharmaceutical or dietary preparations comprising ribose or folic acid or functional analogues thereof, and to the use of these compositions in the prevention or treatment of specific diseases associated with disorders or insufficiencies of total nucleotide metabolism. Background of the invention

[0002] Nucleotides are heterocyclic compounds present in all mammals. Nucleotides consist of a purine or pyrimidine base, a sugar unit and 1-3 phosphate groups. The main purine bases present in the human body are adenine (6-aminopurine), guanine (2-amino-6-hydroxypurine), hypoxanthine (6-hydroxypurine) and xanthine (2,6-di hydroxypurine); the major pyrimidines are uracil (2,4-dihydroxyuracil), cytosine (2,4-dihydroxy-5-methylpyrimidine) and thymine (4-amino-2-hydroxypyrimidine) . The sugar component may be ribose (in ribonucleosides) or 2-deoxyribose. The sugar component is connected to the base at the N9 position of the base t...