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Triterpenoid saponin compound extracting process and orally taken product therewith

A technology of triterpenoid saponins and an extraction method is applied in the field of extraction of triterpenoid saponins and preparation of human oral products, which can solve problems such as unhealthy health of pregnant women, cure symptoms rather than root causes, and achieve the treatment of hyperacidity and inhibition of oral cavity. Bacteria, easy to use effect

Inactive Publication Date: 2007-04-11
GUANGXI HUIBAOYUAN PHARMA TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The usual treatment is to take chemical medicines that neutralize acid and alkali. This kind of medicine is not a cure for the symptoms, and long-term use is not good for pregnant women.

Method used

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  • Triterpenoid saponin compound extracting process and orally taken product therewith

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0075] Example 1 illustrates the steps of extracting mogroside V in the present invention:

[0076] Divide into three groups, mash 100g of Luo Han Guo fresh fruit, add 500ml of water and heat up to 25°C (group 1), 40°C (group 2), 45°C (group 3). Add the hydrolyzate containing the enzyme mixture. The enzymolysis solution contains an equal amount of pectinase, protease, fiber and hemicellulase etc. (enzymolysis solution concentration is respectively 0.005% (group one), 0.15% (group two) and 1% (group three). Enzymolysis 2 Hours (group 1), 30 minutes (group 2), 3 hours (group 3), after 3 hours (group 3), heat up to 120°C (group 1), 100°C (group 2), 85°C (group 3). Use a 40-mesh stainless steel filter After filtering, collect the soluble part. Add 800ml of water to the precipitated part, and evaporate to 600ml of water. After filtering, the solution part is mixed with the previous liquid. Add water to 2000ml. Add 150ml of saturated calcium ion (Ca++), 50ml of saturated sodium ion...

Embodiment 3

[0085] Example 3 demonstrates the efficacy of the invention in treating hyperacidity.

[0086] Triterpene saponins (containing mogroside V) form a 40ml / ml solution in an aqueous glycerin solution. Respectively administered to 10 patients with symptoms of gastric distension or acid regurgitation. In this test, 4 pregnant women, 4 men aged 35 to 65 and 2 non-pregnant women aged 55 to 65 were included. Each patient was given 2 ml of the test article 3 times a day. The table shows the test results.

[0087] Table 2

[0088] Clinical Patient Symptoms Symptoms improved after 30 minutes

[0089] 4 pregnant women Chest swelling / bad breath 85%

[0090] Men (34-65) Chest distension / acid reflux 75%

[0091] Non-pregnant women (55-65 years old) breast swelling 90%

[0092] As shown above, each group of patients received very good treatment results.

Embodiment 4

[0093] Example 4 demonstrates the application of triterpene saponins as ideal non-sugar ingredients in chewing gum products.

[0094] Mogroside V obtained according to the examples, in the following table, is related to the formulation of chewing gum.

[0095] table 3

[0096] Sugar Free Gum Recipe 1

[0097] Raw material W / W

[0098] Gum base 25%

[0099] Sugar Alcohol 67%

[0100] Mogroside V Extract 0.03%-0.8%

[0101]Alcohol soluble licorice fraction 0.01-5%

[0102] Glycerin 6.5%

[0103] Flavoring 1.2%

[0104] According to the display content, after mogroside V and alcohol-soluble licorice are added to the chewing gum, the chewing gum has the characteristics of tooth-friendly effect, good taste and sugar-free. In this ingredient, sugar alcohols include xylitol, carcitol, polyglucose, sorbitol, mannitol, maltitol, starch hydrolyzate.

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Abstract

The present invention relates to the extraction process of triterpenoid saponin compound. Plant material containing triterpenoid saponin is first reacted with enzymolyzing liquid to form solution containing triterpenoid saponin and precipitate, and through filtering, collecting solution and separation, triterpenoid saponin compound is separated. Orally taken triterpenoid saponin product is produced through adding triterpenoid saponin and additive to stuffing. The orally taken triterpenoid saponin product may be used in inhibiting oral cavity bacteria, treating hyperhydrochloria, and preventing and treating peridentitis, halitosis and other diseases.

Description

Technical field: [0001] The invention belongs to the field of prevention and treatment of symptoms such as periodontitis, bad breath and hypersecretion of gastric acid, and in particular relates to a method for extracting triterpene saponins which can inhibit the growth of oral bacteria and eliminate stomach pain, and a human oral product prepared therefrom. Background technique: [0002] Chronic infection and inflammation are common and difficult to treat, especially among the elderly. [0003] For chronic infection and inflammation, antibiotic therapy has been implemented in the West for more than 50 years. Long-term use of antibiotics will lead to drug resistance, because pathogenic microorganisms will produce genetic factor mutations and become drug-resistant strains. [0004] Periodontitis and dental caries are prevalent conditions of chronic disease. Periodontitis can lead to symptoms such as toothache, bad breath, and tooth loss. The root cause of the disease is the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12P33/00A61K31/7028A61P1/02A61P1/14
Inventor 詹姆斯·周
Owner GUANGXI HUIBAOYUAN PHARMA TECH CO LTD