Bactericidal/permeability-increasing protein delation analogs

An analogue and permeability technology, applied in the direction of bactericidal/permeability enhancing protein, peptide/protein component, animal/human protein, etc., can solve the problem that the loss of survival of Gram-negative bacteria has not been reversed, and the correlation has not been obtained clarification and other issues
CN1312858AInactive Publication Date: 2001-09-12XOMA TECH LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
XOMA TECH LTD
Publication Date
2001-09-12
Estimated Expiration
Not applicable · inactive patent

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Abstract

Novel BPI deletion analogs are provided that consist of amino acid residues 10 through 193 of mature human BPI wherein the cysteine residue at BPI amino acid position 132 is replaced by another amino acid. Fusion proteins comprising these analogs are also provided, as are polynucleotides encoding these products, materials and methods for their recombinant production, compositions and medicaments of these products, and therapeutic uses for these products.
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Description

Background of the invention

[0001] The present invention provides novel formulations of biologically active bactericidal / permeability-increasing protein (BPI) deletion analogs and pharmaceutical compositions containing these formulations, wherein the novel analogs are characterized by better stability and uniformity and enhanced in vivo activity.

[0002] BPI is a protein isolated from granules of mammalian blood cells called polymorphonuclear leukocytes (PMNs, or neutrophils) that are critical to defending against invading microbes. BPI is known to bind lipopolysaccharide, a major component of the outer membrane protein of Gram-negative bacteria that stimulates a robust immune response that can lead to septic shock. Human BPI by acid extraction combined with ion-exchange chromatography [Elsbach, J. Biochem., 254:11000 (1979)] or Escherichia coli [E.coli] affinity chromatography [Weiss et al., Blood, 69:652 (1987)] Proteins were isolated from PMNs. BPI obtained in this way ...

Claims

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