Bicarbonate-based solution in two parts for peritoneal dialysis or substitution in continuous renal replacement therapy

A technology of bicarbonate and sodium bicarbonate is applied in peritoneal dialysis, devices that make medicines into special physical or oral forms, dialysis systems, etc. and other issues, to achieve the effect of low cost
CN1336825AInactive Publication Date: 2002-02-20BAXTER INT INC
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
BAXTER INT INC
Publication Date
2002-02-20
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention provides devices and methods for stabilizing bicarbonate-based solutions for peritoneal dialysis or hemofiltration. The bicarbonate-based solutions of the present invention are formulated and stored in at least two parts - an alkaline bicarbonate concentrate and an acidic concentrate. The alkaline bicarbonate concentrate is adjusted to have a pH of about 8.6 to 10.0. The acidic concentrate is adjusted to have a stable, acidic pH ranging from about 1.0 to 3.0. Upon mixing, although some variation in the pH of the mixed bicarbonate solution exists, the inventors have discovered that with the appropriate selection of the parameters of the concentrates, the pH of the mixed solution is always within an acceptable physiological range.
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Description

Background of the invention

[0001] The present invention relates to peritoneal dialysis or renal replacement therapy, such as hemofiltration and hemodiafiltration. In particular, the invention relates to the preparation and storage of bicarbonate-based solutions for peritoneal dialysis and hemofiltration.

[0002] To overcome the shortcomings of traditional hemodialysis, other techniques such as peritoneal dialysis and hemofiltration have been developed. Peritoneal dialysis uses the patient's own peritoneum as a semipermeable membrane. As the inner membrane of the body cavity, the peritoneum can be used as a natural semi-permeable membrane due to the richness of a large number of blood vessels and capillaries.

[0003] During peritoneal dialysis, a catheter is used to introduce sterile dialysate into the peritoneal cavity. Solute exchange between dialysate and blood is achieved over a sufficiently long time. Fluid flow is achieved by forming an appropriate osmotic gradient...

Claims

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