Medicinal composition for target direction transport curing cancer and its usage

A composition and targeted technology, which can be applied in the direction of drug combination, gene therapy, pharmaceutical formulation, etc., can solve the problem of short circulation half-life

Inactive Publication Date: 2002-11-06
THE HONG KONG UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

A potential problem with antibody-encapsulated liposomes is that they may be more immunogenic, resulting in a shorter circulating half-life

Method used

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  • Medicinal composition for target direction transport curing cancer and its usage
  • Medicinal composition for target direction transport curing cancer and its usage
  • Medicinal composition for target direction transport curing cancer and its usage

Examples

Experimental program
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Effect test

experiment example

[0044] Materials and methods

[0045] Material

[0046] L-α-phosphatidylcholine (PC), cholesterol (Chol), α1 acid glycoprotein, doxorubicin hydrochloride (Dox), N-hydroxysuccinimidyl-biotin (NHSB) and neuraminidase Purchased from Sigma Corporation (St. Louis, MO). Avidin and dipalmitoylphosphatidylserine (PS) were purchased from Calbiochem (San Diego, CA). RPMI 1640 medium, fetal bovine serum, penicillin and streptomycin were purchased from Gibco Life Technologies (Grand Island, NY).

[0047] cell culture

[0048] Human hepatoblastoma (HepG2) was obtained from the American Type Culture Collection (Rockville, MD) and maintained in RPMI 1640 medium supplemented with 5% fetal bovine serum, 100 units / ml penicillin and 100 μg / ml streptomycin at saturated humidity with 5% CO 2 cultured in an incubator. cells at 1 x 10 4 Cells / well were seeded into 96-well culture plates or 1×10 5 Cells / well were seeded into 24-well culture plates and incubated for 18-22 hours for treatment. ...

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Abstract

The present invention provides a medicine composition with medicine capsulated in liposome, which is coupled with some asialoglycoprotein, such as asialoglycoprotein alpha 1. The present invention also provides a method of transporting the medicine composition to the acceptor tissue. The present invention also provides a method of applying medicine composition containing amycin to inhibit the proliferation of liver cancer cell with the amycin being capsulated in liposome coupled with asialoglycoprotein alpha 1.

Description

technical field [0001] The present invention relates to the fields of drug delivery, pharmacology and cancer chemotherapy. Background technique [0002] Throughout the present disclosure, numbers in parentheses are references to various published publications. At the end of the specification are references in alphabetical order. The contents of these references are hereby incorporated into the present invention in order to more fully describe the state of the art in the field to which this invention pertains. [0003] Most of the cytotoxic drugs used in cancer chemotherapy have a narrow chemotherapeutic utility and severe side effects at high doses. Therefore, drug delivery systems have been developed to alter the biodistribution of cytotoxic drugs, improve their selectivity for tumors or lessen their damage to normal tissues. In this regard, liposomes have been widely used. Liposomes as drug delivery systems offer a way to improve upon the therapeutic use of traditional...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/127A61K38/16A61K48/00
CPCA61K9/1271A61K38/16A61K48/00A61P35/00
Inventor 王子晖曾瑞英
Owner THE HONG KONG UNIV OF SCI & TECH
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