Medicinal composition for target direction transport curing cancer and its usage

A composition and targeted technology, which can be applied in the direction of drug combination, gene therapy, pharmaceutical formulation, etc., can solve the problem of short circulation half-life
CN1377707AInactive Publication Date: 2002-11-06THE HONG KONG UNIV OF SCI & TECH
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Patent Information

Authority / Receiving Office
CN Ā· China
Patent Type
Applications(China)
Current Assignee / Owner
THE HONG KONG UNIV OF SCI & TECH
Publication Date
2002-11-06
Estimated Expiration
Not applicable Ā· inactive patent

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Abstract

The present invention provides a medicine composition with medicine capsulated in liposome, which is coupled with some asialoglycoprotein, such as asialoglycoprotein alpha 1. The present invention also provides a method of transporting the medicine composition to the acceptor tissue. The present invention also provides a method of applying medicine composition containing amycin to inhibit the proliferation of liver cancer cell with the amycin being capsulated in liposome coupled with asialoglycoprotein alpha 1.
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Description

technical field

[0001] The present invention relates to the fields of drug delivery, pharmacology and cancer chemotherapy. Background technique

[0002] Throughout the present disclosure, numbers in parentheses are references to various published publications. At the end of the specification are references in alphabetical order. The contents of these references are hereby incorporated into the present invention in order to more fully describe the state of the art in the field to which this invention pertains.

[0003] Most of the cytotoxic drugs used in cancer chemotherapy have a narrow chemotherapeutic utility and severe side effects at high doses. Therefore, drug delivery systems have been developed to alter the biodistribution of cytotoxic drugs, improve their selectivity for tumors or lessen their damage to normal tissues. In this regard, liposomes have been widely used. Liposomes as drug delivery systems offer a way to improve upon the therapeutic use of traditional...

Claims

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