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A kind of method of modified chitosan

A chitosan modification technology, applied in the field of modified chitosan, can solve the problems of weak specific recognition, complicated operation, inability to target recognition of asialoglycoprotein, etc. Moderate, cost-reducing effect

Active Publication Date: 2016-08-24
HEILONGJIANG HEIKE TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The present invention solves the problem that the operation of the traditional modification method is relatively complicated, mainly depends on the size and surface properties of the particles, the specific recognition is not strong, and it cannot be targeted and recognized by the asialoglycoprotein in the liver parenchymal cells, thereby providing a Method for modifying chitosan

Method used

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  • A kind of method of modified chitosan
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specific Embodiment approach 1

[0020] Specific embodiment one: the method for a kind of modified chitosan described in the present embodiment is specifically carried out according to the following steps:

[0021] 1. Dissolving chitosan in dilute hydrochloric acid solution with a mass fraction of 1% to 20% to obtain acidified chitosan;

[0022] The volume ratio of the quality of the chitosan to the dilute hydrochloric acid solution with a mass fraction of 1% to 20% is 1g:(100 to 300) mL;

[0023] 2. Dissolving lactobionic acid in water to obtain a lactobionic acid solution;

[0024] The mass of the lactobionic acid and the volume ratio of water are 1g:(10~50)mL;

[0025] 3. Dissolving N,N'-dicyclohexylcarbodiimide in tetramethylethylenediamine to obtain activated N,N'-dicyclohexylcarbodiimide;

[0026] The volume ratio of the mass of N,N'-dicyclohexylcarbodiimide to tetramethylethylenediamine is 1g:(10-50)mL;

[0027] 4. Drop lactobionic acid solution and activated N,N'-dicyclohexylcarbodiimide into the a...

specific Embodiment approach 2

[0031] Specific embodiment two: what this embodiment is different from specific embodiment one is: the quality of the chitosan described in step one and the volume ratio of the dilute hydrochloric acid solution of 1%~20% are 1g:(100~ 200) mL. Others are the same as in the first embodiment.

specific Embodiment approach 3

[0032] Embodiment 3: This embodiment differs from Embodiment 1 or Embodiment 2 in that: the volume ratio of the mass of lactobionic acid described in step 2 to water is 1 g:(20-50) mL. Others are the same as in the first or second embodiment.

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Abstract

A method for modifying chitosan, the invention relates to a method for modifying chitosan. The invention aims to solve the problem that the traditional modification method is relatively complicated to operate, mainly depends on the size and surface properties of the particles, and the specific recognition is not strong, and the problem that the asialoglycoprotein in the liver parenchymal cells cannot be targeted and recognized. Method: Dissolve chitosan in dilute hydrochloric acid solution to obtain acidified chitosan; dissolve lactobionic acid in water to obtain lactobionic acid solution; dissolve N,N′-dicyclohexylcarbodiimide in tetramethyl In ethylenediamine, the activated N,N'-dicyclohexylcarbodiimide is obtained; the lactobionic acid solution and the activated N,N'-dicyclohexylcarbodiimide are dropped into the acidified chitosan to obtain The mixture is filtered and dialyzed with a dialysis bag, and then vacuum-dried to obtain the modified chitosan. The invention is a method for modifying chitosan.

Description

technical field [0001] The invention relates to a method for modifying chitosan. Background technique [0002] Because chitosan is cationic, it is a biodegradable and biocompatible, safe and non-toxic natural polymer, and the active group amino group and hydroxyl group in the structure can be further modified to carry receptor-mediated targeting groups, so It is an ideal coating material for negatively charged particles. However, chitosan itself has a strong rigid crystal structure and can only be dissolved in an acidic environment (pH<5), insoluble in water and general organic solvents, and has little advantage when used alone. In order to improve the defects of chitosan, broaden chitosan The application of sugar in the field of pharmaceutical preparations, the research on its chemical modification is increasing day by day. [0003] Acylated chitosan has been synthesized a lot at home and abroad, and it is gradually used as a drug carrier. For example, N-acylation of ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08B37/08
Inventor 陈明月姜海健马宇良苏桂明方雪姚立明张晓臣何冬青宋美慧
Owner HEILONGJIANG HEIKE TECH CO LTD
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