Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Vaccine for treatment of tubercolosis and other intracellular infections diseases and preparing process thereof

A technology for tuberculosis and vaccines, which is applied in the field of vaccines and preparations for treating tuberculosis and other intracellular infectious diseases, and can solve problems such as non-recommended use and BCG disease transmission

Inactive Publication Date: 2003-05-28
COUNCIL OF SCI & IND RES
View PDF1 Cites 6 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

BCG is now used as an attenuated preparation and is not recommended in the above subjects because it can lead to the spread of BCG disease

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Vaccine for treatment of tubercolosis and other intracellular infections diseases and preparing process thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0017] The novelty of the present invention is that the protective antigen secreted by mycobacteria in macrophages can be used as a vaccine without isolation from macrophages.

[0018] The vaccine is administered after radiation exposure, and irradiated cells are known to undergo apoptosis. Cells undergoing apoptosis are phagocytized by dendritic cells. Dendritic cells activate naive T cells to differentiate into Th1 cells and cytotoxic cells. These cells are known to play a major role in protective immunity against intracellular infection and cancer.

[0019] Allogeneic macrophages in the system generate an allogeneic response, thereby producing a large number of cytokines such as IL-2, IL-12, IFN-γ, etc., which can stimulate Th1 responses and cell-mediated immune response. Allogeneic cells used in vaccine construction elicit an immune response independent of genetic background, that is, it acts as a promiscuous vaccine. Therefore, it can be used in humans regardless of g...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention relates to a process for the preparation of a vaccine against tuberculosis and other intracellular pathogens, thie vaccine is targeted against intracellular pathogens, more particularly the pathogen Mycobacterium tuberculosis and Salmonella in this case.

Description

technical field [0001] The invention relates to a preparation method of a vaccine against tuberculosis and other intracellular pathogens, the vaccine is aimed at the intracellular pathogens, especially Mycobacterium tuberculosis and Salmonella pathogens. The use of the present invention is the development of a vaccine against intracellular pathogens such as tuberculosis, brucellosis, leishmaniasis, leisteriosis, leprosy, malaria, typhoid, trypanosomiasis, streptococcus and HIV infection of pathogens. The subject of the present invention, the pathogen M. tuberculosis, is a causative agent of tuberculosis. In the present invention, M. tuberculosis is grown in allogeneic and syngeneic macrophages and macrophage cell lines. The macrophage-M. tuberculosis complex is then irradiated, killing both the macrophage and the mycobacteria. Background of the invention [0002] Tuberculosis is a chronic infectious disease that kills about 3 million people every year. About 8 million pe...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K39/00A61K39/02A61K39/04A61K39/112A61K47/48A61P31/04A61P31/06A61P31/18A61P33/02A61P35/00
CPCA61K47/48776A61K39/0275A61K39/0005A61K2039/521A61K2039/5154A61K39/04A61K47/6901A61P31/04A61P31/06A61P31/18A61P33/02A61P35/00Y02A50/30
Inventor J·N·阿格勒瓦拉N·沙尔玛
Owner COUNCIL OF SCI & IND RES
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com