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Vaccine for treatment of tubercolosis and other intracellular infections diseases and preparing process thereof

A tuberculosis and vaccine technology, which is used in the field of vaccines for the treatment of tuberculosis and other intracellular infections and their preparation, and can solve the problems of BCG disease transmission and non-recommended use.

Inactive Publication Date: 2009-06-10
COUNCIL OF SCI & IND RES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

BCG is now used as an attenuated preparation and is not recommended in the above subjects because it can lead to the spread of BCG disease

Method used

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  • Vaccine for treatment of tubercolosis and other intracellular infections diseases and preparing process thereof

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Effect test

Embodiment Construction

[0017] The novelty of the present invention is that the protective antigen secreted by mycobacteria in macrophages can be used as a vaccine without isolation from macrophages.

[0018] The vaccine is administered after radiation exposure, and irradiated cells are known to undergo apoptosis. Cells undergoing apoptosis are phagocytized by dendritic cells. Dendritic cells activate naive T cells to differentiate into Th1 cells and cytotoxic cells. These cells are known to play a major role in protective immunity against intracellular infection and cancer.

[0019] Allogeneic macrophages in the system generate an allogeneic response, thereby producing a large number of cytokines such as IL-2, IL-12, IFN-γ, etc., which can stimulate Th1 responses and cell-mediated immune response. Allogeneic cells used in vaccine construction elicit an immune response independent of genetic background, that is, it acts as a promiscuous vaccine. Therefore, it can be used in humans regardless of g...

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Abstract

The present invention relates to a process for the preparation of a vaccine against tuberculosis and other intracellular pathogens, this vaccine is targeted against intracellular pathogens, more particularly the pathogen Mycobacterium tuberculosis and Salmonella in this case.

Description

technical field [0001] The invention relates to a preparation method of a vaccine against tuberculosis and other intracellular pathogens, the vaccine is aimed at the intracellular pathogens, especially Mycobacterium tuberculosis and Salmonella pathogens. The use of the present invention is the development of a vaccine against intracellular pathogens such as tuberculosis, brucellosis, leishmaniasis, leisteriosis, leprosy, malaria, typhoid, trypanosomiasis, streptococcus and HIV infection of pathogens. The subject of the present invention, the pathogen M. tuberculosis, is a causative agent of tuberculosis. In the present invention, M. tuberculosis is grown in allogeneic and syngeneic macrophages and macrophage cell lines. The macrophage-M. tuberculosis complex is then irradiated, killing both the macrophage and the mycobacteria. Background of the invention [0002] Tuberculosis is a chronic infectious disease that kills about 3 million people every year. About 8 million pe...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K39/02A61K39/002A61K39/21A61K41/00A61P31/04A61P31/06A61P31/18A61P33/02A61P35/00G01N33/50A61K39/00A61K39/04A61K39/112A61K47/48
CPCA61K47/48776A61K39/0275A61K39/0005A61K2039/521A61K2039/5154A61K39/04A61K47/6901A61P31/04A61P31/06A61P31/18A61P33/02A61P35/00Y02A50/30
Inventor J·N·阿格勒瓦拉N·沙尔玛
Owner COUNCIL OF SCI & IND RES
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