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Freeze dried cyclovirobuxine injection powder for treating cardiac and cerebral vasular diseases

A technology for cardiovascular and cerebrovascular diseases and freeze-dried powder injections, which is applied in the field of drugs with cyclovir buxicine D as the active ingredient, which can solve the problem of slow onset of action, affecting the popularization and application of Huang Yangning tablets, and not suitable for patients who have difficulties in oral administration, etc. problems, to achieve the effect of improved utilization rate, no change in efficacy and appearance, and cheap raw materials

Inactive Publication Date: 2003-09-10
钱毓洲
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this Huangyangning tablet, like the tablets of other medicines, has a slow onset of action and cannot be applied to patients who have difficulties in oral administration or patients with digestive system diseases.
Therefore, it has affected the further popularization and application of Huangyangning Tablets.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Under clean conditions that meet the pharmaceutical requirements, suspend 10g of Cyclovirubuxin D crystalline powder in 500ml of water for injection, add 10g of mannitol (excipient), stir and add sodium dihydrogen phosphate (acidic substance) to adjust the pH value After dissolving completely, use a small amount of injection to decolorize with activated carbon and ultra-filter to obtain a pyrogen-free clear liquid, which is divided into empty penicillin bottles according to the D2mg content of cyclovir buxicine in each bottle, and freezes with known freeze-drying process. dried to prepare a freeze-dried powder injection of Buyangning with a specification of 2 mg / bottle.

Embodiment 2

[0016] Except that phosphoric acid was used instead of sodium dihydrogen phosphate, and 10 g of lactose was used instead of mannitol, all the others were made into a freeze-dried powder injection of Buyang Ning with a specification of 2 mg / bottle according to Example 1.

Embodiment 3

[0018] Except replacing sodium dihydrogen phosphate with tartaric acid, except that with 100g mannitol, all the other all make the buyangning freeze-dried powder injection that specification is 2mg / bottle by embodiment 1.

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PUM

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Abstract

The freeze dred cyclovirobuxine injection powder for treating cardiac and cerebral vascular diseases contains cyclovirobuxine 0.1-20 mg as effective component, acid matter in the amount of making the injection pH value becoem 4.0-7.0, and excipient of 0-999 times the weight of cyclovirobuxine. Mouse experiment probes the toxicity of the present invention meeting the clinical requirement. The injection power may be preserved in lightproof and sealing condition for two years without change in medicinal effect and appearance. The cyclovirobuxine preparation has fast effect and ever wide application range.

Description

technical field [0001] The invention relates to a boxywood freeze-dried powder injection for treating cardiovascular and cerebrovascular diseases, in particular to a medicine with cyclovirboxycin D as an active ingredient. Background technique [0002] At present, cardiovascular and cerebrovascular diseases are not only common and frequently occurring diseases of middle-aged and elderly people, but also becoming common and frequently occurring diseases of young people. Chinese invention patent 92107315.1 discloses a tablet prepared from Cycloviric buxicus D isolated and extracted from Buxus lobularis. This kind of tablet is Huangyangning Tablets, which is composed of Cycloviral Buxusin D, powdered sugar, starch and dextrin. It has been clinically used, and the total effective rate of treating angina pectoris is 90%, and the total effective rate of treating arrhythmia is 100%. 80%. The Pharmacopoeia of the People's Republic of China (2000 edition) also stipulates the Buyang...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/19A61P9/10
Inventor 钱毓洲
Owner 钱毓洲
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