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Production process and application of marine sulfate polysaccharide 20001

A sulfated polysaccharide and a manufacturing method technology are applied in the directions of medical preparations containing active ingredients, pharmaceutical formulations, organic active ingredients, etc., and can solve the problems of few polysaccharide virus inhibitors and the like

Inactive Publication Date: 2004-04-07
OCEAN UNIV OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Many natural polysaccharides and chemically modified polysaccharides have obvious inhibitory effects on various membraned viruses, and their effects are related to the structure, substituent groups, molecular weight, solubility, viscosity, etc. of the polysaccharides. Due to some key technical problems in the research and development of glycoengineering drugs have been resolved, so few polysaccharide viral inhibitors have entered clinical use

Method used

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  • Production process and application of marine sulfate polysaccharide 20001

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Embodiment Construction

[0007] A method for manufacturing marine sulfated polysaccharide 20001 (hereinafter referred to as 20001): prepare alginic acid with water to form a 2% uniform glue solution. Add sulfuric acid, stir, condense and reflux in a water bath at 100°C for 4-6 hours, centrifuge the hydrolysis mixture at 3000rpm for 40 minutes, discard the supernatant, and add 5% Na to the precipitate obtained 2 CO 3 Dissolve the aqueous solution, then add acid solution while stirring the solution, adjust the pH value to a certain range, there will be flocculent precipitation, centrifuge at 3000rpm for 40 minutes, add 95% ethanol to the obtained supernatant to make the concentration reach 30%, and the solution will be layered Remove the precipitate, add ethanol to the supernatant to make the concentration reach 70%, dissolve the precipitate part with formamide, add quantitative chlorosulfonic acid and PAB-A acid raw materials, react with ethanol after 6-8 hours, and the precipitate is formulated as 10...

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Abstract

The present invention features that alginic acid is processed through acid degradation, separation and purification, sulfuric acid modification and membrane separation to produce marine sulfate polysaccharide 20001 of molecular weight about 4000. The marine sulfate polysaccharide 20001 is used in preparing antiviral preparation, widely used in resisting virus.

Description

Technical field: [0001] The invention relates to a manufacturing method and application of marine sulfated polysaccharides 20001. Background technique: [0002] Viral infectious diseases are a class of common diseases that seriously endanger human health at present, and there is a lack of effective prevention and treatment drugs in clinic. Many natural polysaccharides and chemically modified polysaccharides have obvious inhibitory effects on various membraned viruses, and their effects are related to the structure, substituent groups, molecular weight, solubility, viscosity, etc. of the polysaccharides. Due to some key technical problems in the research and development of glycoengineering drugs been resolved, so few polysaccharide virus inhibitors have entered clinical application. Invention content: [0003] The purpose of the present invention is to provide a kind of manufacture method of marine sulfated polysaccharide substance 20001, and this product is used for prepa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/734C08B37/04
Inventor 耿美玉辛现良管华诗李静
Owner OCEAN UNIV OF CHINA