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Triglyceride depressant composition

A triglyceride and composition technology, applied in the field of blood triglyceride lowering agent composition, can solve problems such as determination of failure to reach correlation

Inactive Publication Date: 2004-04-14
SANKYO CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The relationship between blood triglyceride levels and atherosclerotic disease has not yet been established as clearly as that seen between blood cholesterol and coronary atherosclerotic disease

Method used

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  • Triglyceride depressant composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] (Example 1) tablet

[0032] (1) Ingredients

[0033] Table 1

[0034]

[0035] 4 out of 4 out of 4

[0036] (1600mg) (1440mg)

[0037] Pravastatin Sodium 20mg 20mg

[0038] Riboflavin Butyrate 12mg -

[0039] Ascorbic acid 500mg -

[0040]dl-alpha-tocopheryl succinate 200mg -

[0041] Dipantethine - 500mg

[0042] Crystalline Cellulose 120mg 12mg

[0043] Magnesium aluminosilicate 144mg -

[0044] Sucrose fatty acid esters - 140mg

[0045] Hydroxypropyl Cellulose 96mg 48mg

[0046] Magnesium Stearate 24mg 24mg

[0047] Crospovidone 100mg 48mg

[0048] (crospopidon)

[0049] Lactose appropriate amount

[0050] Table 2

[0051]

[0052] 4 out of 4 out of 4

[0053] (1400mg) (1400mg)

[0054] Pravastatin Sodium 20mg 20mg

[0055] Inositol Niacinate 500mg -

[0056] Ascorbic Acid - 500mg

[0057]...

Embodiment 2

[0066] (embodiment 2) fine granule

[0067] (1) Ingredients

[0068] table 3

[0069]

[0070] 4 packs 4 packs

[0071] (5.5g) (5.2g)

[0072] Pravastatin Sodium 20mg 20mg

[0073] Riboflavin Butyrate 12mg -

[0074] Ascorbic acid 1.0g -

[0075] dl-alpha-tocopheryl succinate 200mg -

[0076] Dipantethine - 500mg

[0077] Refined white sugar 1.4g 1.6g

[0078] Stevia Chrysanthemum Extract - 16mg

[0079] Corn starch 1.2g 1.2g

[0080] Polysorbate 80 80mg 48mg

[0081] Magnesium aluminosilicate 144mg -

[0082] Magnesium Stearate 24mg 24mg

[0083] Lactose appropriate amount

[0084] Table 4

[0085]

[0086] 4 packs 4 packs

[0087] (5g) (5g)

[0088] Pravastatin Sodium 20mg 20mg

[0089] Inositol Niacinate 1000mg -

[0090] Ascorbic Acid - 1000mg

[0091] dl-alpha-tocopheryl succinate - 200mg ...

Embodiment 3

[0101] (embodiment 3) capsules

[0102] (1) Ingredients

[0103] table 5

[0104]

[0105] of 8 capsules of 8 capsules

[0106] Pravastatin Sodium 20mg 20mg

[0107] Riboflavin Butyrate 12mg -

[0108] Ascorbic acid 500mg -

[0109] dl-alpha-tocopheryl succinate 200mg -

[0110] Dipantethine - 500mg

[0111] Corn starch 960mg 960mg

[0112] Polysorbate 80 80mg 48mg

[0113] Magnesium aluminosilicate 144mg -

[0114] Magnesium Stearate 24mg 24mg

[0115] Lactose appropriate amount

[0116] Subtotal 2000mg 1940mg

[0117] Capsules 640mg 640mg

[0118] Total 2640mg 2580mg

[0119] Table 6

[0120]

[0121] of 8 capsules of 8 capsules

[0122] Pravastatin Sodium 20mg 20mg

[0123] Inositol Niacinate 500mg -

[0124] Ascorbic Acid - 500mg

[0125] dl-alpha-tocopheryl succinate - 200mg

[0126] Corn starch 960mg 960mg

[0127] Polysorbate 80 80mg 48mg

[0128] Magn...

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Abstract

A blood triglyceride depressant composition which comprises pravastatin and one or more members selected from the group consisting of (1) pantethine, (2) inositol hexanicotinate, (3) a combination drug containing a riboflavin compound, a tocopherol compound and an ascorbic acid compound, and (4) a combination drug containing a tocopherol compound and an ascorbic acid compound.

Description

technical field [0001] The present invention relates to a blood triglyceride lowering agent composition, the composition contains pravastatin (pravastatin), and selected from ① bispantethine, ② inositol nicotinate, ③ riboflavin, One or two or more of mixtures consisting of tocopherols and ascorbic acids and (4) mixtures consisting of tocopherols and ascorbic acids. Background technique [0002] The relationship between blood triglyceride levels and arteriosclerotic disease has not been established as clearly as that seen between blood cholesterol and coronary arteriosclerotic disease. However, the importance of blood triglycerides as a risk factor for arteriosclerotic diseases has been clarified clinically, and it has also been clarified that difficult hypertriglyceridemia causes insulin resistance, and Deep relationship with arteriosclerosis (Document: For example, Modern Physician, Vol. 18 No. 11998, p.53-56 and p.69-71). [0003] On the other ha...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/355A61K31/16A61K31/22A61K31/225A61K31/235A61K31/366A61K31/375A61K31/444A61K31/455A61K31/498A61K31/519A61K31/525A61P3/06A61P43/00
CPCA61K31/525A61K31/366A61K31/519A61K31/498A61K31/355A61K31/444A61K31/455A61K31/16A61K31/225A61K31/375A61K31/22A61P3/06A61P43/00A61K2300/00
Inventor 大泽常起高木郁夫清水一平近藤达仁中山正人鸟住保博
Owner SANKYO CO LTD
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