4 results about "Magnesium aluminosilicate" patented technology

The invention relates to chemistry, medicine and pharmacy, in particular to the composition of a pharmaceutical composition based on a silicon sorbent and a method of its manufacture, and can be used in various sectors of the national economy, namely, for wastewater treatment and pharmaceutical preparations for enteral detoxification. A composition in which 1 mass fraction of a silicon sorbent in the form of a gel selected from the group of silicon dioxide, polymethyl siloxane with a particle size of up to 400 microns comprises from 0.1 to 10 mass fractions of an aluminum compound, preferably selected from the group of: aluminum hydroxide, aluminummagnesium hydroxide, magnesium aluminosilicate, aluminum phosphate, previously dissolved in water to the form of a gel. A method in which 1 part by mass of a silica sorbent in the form of a gel selected from the group: silicon dioxide, polymethylsiloxane polyhydrate with a particle size of up to 400 microns is mixed with 0.1 to 10 parts of an aluminum compound, preferably selected from the group: aluminum hydroxide, aluminummagnesium hydroxide, magnesium aluminosilicate, aluminum phosphate, zinc oxide, zinc stearate, zinc podolate, zinc sulfate, pre-dissolved in water, after which the mixture is subjected to mechanical treatment with a mixer at a frequency of from 100 to 3000 rpm or homogenized using a homogenizer at a frequency of from 100 to 3000 rpm. The pharmaceutical composition prepared by this method is convenient for oral administration, has a significant adsorbing effect and can be used in large quantities for a single therapeutic dose.

A method for purifying a branched polyethylene glycol, which includes adding, to a branched polyethylene glycol compound represented by the following formula [1] and having a weight average molecular weight of 40,000 or more:where Z, Y1, Y2, A, Polymer, l, m and b are as defined herein, at least one solid acid selected from magnesium silicate, aluminum silicate, and aluminum magnesium silicate and having a specific surface area of 50 to 250 m2 / g in the presence of an aprotic organic solvent to obtain a mixture; stirring the mixture; and subsequently separating the solid acid.

The application belongs to the technical field of pharmaceutical preparations, and particularly relates to a self-emulsifying nanometer preparation of tofacitinib and a preparation method thereof. The tofacitinib free base is mixed with diethylene glycol monoethyl ether, and is dissolved by heating and oscillation; then polyoxyethylene 40 hydrogenated castor oil and glyceryl monocaprylate are added, and are uniformly stirred to obtain a drug-containing SEDDS solution; the SEDDS solution is added dropwise into magnesium aluminosilicate to obtain a SEDDS solidified powder. The method significantly improves the solubility and stability of the tofacitinib free base, simplifies the production process, improves the bioavailability and safety of the drug, provides various preparation forms, and meets the medication needs of different patients.

The invention relates to the technical field of radiation refrigeration materials, in particular to a method for preparing a calcium magnesium silicate radiation refrigeration coating based on yellow phosphorus slag, which comprises the following steps: S1, mixing the yellow phosphorus slag and magnesium oxide according to the weight ratio of (2: 1)-(10: 1), and ball-milling to obtain precursor powder; s2, sintering the precursor powder at 800-1200 DEG C for 4-12 hours to generate a calcium magnesium silicate primary reaction product; s3, ball-milling and sieving the primary reaction product to obtain the calcium magnesium silicate radiation refrigeration powder material with the particle size of 800-4000 meshes; s4, mixing aluminum dihydrogen phosphate, calcium magnesium silicate powder and water according to the mass ratio of (1: 2: 1)-(1: 3: 2), adding a dispersing agent, a wetting agent, a flatting agent and a defoaming agent, and uniformly stirring to obtain a radiation refrigeration coating; and S5, the surface of a solid substrate is coated with the radiation refrigeration coating to form a wet coating, and the radiation refrigeration coating is obtained after drying. The coating disclosed by the invention is easy to produce and has a good application prospect in the building industry.