6 results about "Blood triglycerides" patented technology

The application belongs to the technical field of medicine, and discloses a kind of optical compound and its preparation method and application, specifically discloses the enantiomer has different effect.In vitro experiment, enantiomer shows selectivity to target point, S-isomer tends to activate PPARγ, and R-isomer tends to activate FFAR1.In animal model, the efficacy of enantiomer also shows difference, first, two enantiomers can significantly reduce the blood sugar of animal, and significantly improve the insulin resistance of animal.However, in reducing blood triglyceride, the effect of S-isomer is obviously superior to racemate and R-isomer, and in reducing blood cholesterol, the effect of R-isomer is obviously superior to racemate and S-isomer.Therefore, (S)‑1 has important role in preparing blood sugar reducing, triglyceride reducing drug, and (R)‑1 has more significant effect in reducing blood sugar, reducing cholesterol, and has important significance for clinical targeted treatment and application.

The present invention relates to a composition for regulating hepatic lipid metabolism, comprising Lactiplantibacillus plantarum OPT-A1 strain deposited under accession number KCTC 15555BP, a culture liquid thereof, a cultured product thereof, or a culture lysate thereof. The composition suppresses lipid accumulation and expression of genes related to lipogenesis in hepatocytes, and enhances expression of genes related to lipid oxidation. In addition, the composition inhibits accumulation of triglycerides in hepatocytes and reduces blood triglyceride levels, total cholesterol levels, and liver injury indices. Furthermore, the composition promotes rapid consumption of lipids in hepatocytes and somatic cells through enhancement of muscle mass, and thus can be advantageously used as a raw material for foods, pharmaceuticals, and the like related to alleviation and treatment of various metabolic diseases.

The present application belongs to the field of analytical chemistry and electrochemistry, and particularly relates to an electrochemical sensor, a preparation method and application thereof in detection of sweat triglyceride content. A wearable sensor is prepared based on C-ZIF-67 / KB nanocomposite material, the sensor realizes detection of sweat triglyceride for the first time, and it is verified that sweat triglyceride level has high correlation with blood triglyceride level (correlation coefficient is 0.813, n=35). Through verification of a commercial colorimetric analysis kit, the sensor obtains a high correlation coefficient of 0.853 in detection of sweat triglyceride, which shows excellent accuracy.

A gene editing system comprising: (a) a gene editor fusion protein comprising a Cas protein and a deaminase, or a nucleic acid encoding the gene editor fusion protein, and (b) a hybrid guide nucleic acid comprising a spacer sequence, wherein the spacer sequence comprises at least one deoxyribonucleotide and a plurality of ribonucleotide is claimed. A 2’ hydroxyl group of a ribose on at least one ribonucleotide may be covalently linked to a methyl group (2’-OMe). The gene editing system for use in treating or preventing an atherosclerotic cardiovascular disease, or lowering blood low-density lipoprotein cholesterol (LDL-C) levels or lowering blood triglyceride levels is further claimed. [None]

The application provides biomass fiber aerogel and a preparation method and application thereof, and specifically, the aerogel comprises nanoparticles and biomass fibers, the nanoparticles are arranged on surfaces of the biomass fibers; the nanoparticles comprise shellac; and the biomass fibers comprise chitin.The aerogel has micro-plastic removal and lipid metabolism regulation functions, can be adapted to oil-water mixed systems of different oil types and different oil concentrations, can maintain structural stability and high adsorption performance in a complex static / dynamic digestion environment, and can reduce fat accumulation in the body, reduce blood triglyceride content, promote excretion of lipid feces and regulate lipid metabolism.In addition, the aerogel has good biocompatibility, is biodegradable, has no risk of in-vivo accumulation and has good clinical safety.

The invention provides bacillus natto and application, and belongs to the technical field of microorganisms. The bacillus natto disclosed by the invention is bacillus natto DG2-7 which is preserved in the China General Microbiological Culture Collection Center (CGMCC) and has the preservation number of CGMCC No.36482, and relates to application of the bacillus natto DG2-7 in improvement of intestinal functions and body metabolism. The strain can be used for preparing natto, natto powder, natto tablets and other preparations, has the effects of regulating constipation, diarrhea, flatulence, sour regurgitation and bad breath, can assist in reducing blood triglyceride and relieving gout, and is beneficial to relieving female dysmenorrhea. In a test, good intestinal regulation and metabolism improvement effects are shown, and the comprehensive function is superior to that of a commercially available probiotic product.