54 results about "Blood triglycerides" patented technology

The present invention provides a dietary supplement and methods of using the same to promote body weight reduction and / or loss of body fat in a subject, and for the management of obesity. The supplement can further be used to reduce one or more metabolic parameters in a subject, such as blood glucose levels, blood triglyceride levels, and blood cholesterol levels.

The invention relates to compounds which are polysufated oligosaccharide derivatives having activity as inhibitors of heparan sulfate-binding proteins and inhibitors of the enzyme heparanase; methods for the preparation of the compounds; compositions comprising the compounds, and use of the compounds and compositions thereof for the antiangiogenic, antimetastatic, anti-inflammatory, antimicrobial, anticoagulant and / or antithrombotic treatment, lowering of blood triglyceride levels and inhibition of cardiovascular disease of a mammalian subject.

The present invention relates to Cucurbitaceae plant extracts or purified extracts isolated therefrom having anti-adipogenic and anti-obesity activities, and compositions comprising them. Cucurbitaceae plant extract of the present invention exhibits effective body weight-lowering activity, lowering blood triglyceride and cholesterol content, activating PPARα and δ activity, reducing stearoyl-CoA dehydrogenase gene expression activity and preventing preadipocytes Adipogenesis activity, and no toxicity, therefore, those extracts can be used as medicine or health food for the treatment or prevention of obesity and diseases involving adipogenesis.

The invention provides a vitamin E collagen beverage. The vitamin E collagen beverage comprises the following components of collagen powder, fructose, vitamin C, vitamin E, sodium alginate, sucralose, citric acid, fruity essence and the balance of purified water. The vitamin E collagen beverage disclosed by the invention has the efficacy of beautifying faces, nourishing faces, resisting wrinkles, enabling freckles to be lighter and dispelling freckles on drinking crowds, cannot cause side effects to human bodies after being drunk for a long term, can reduce blood triglyceride and cholesterol, can reduce damage of aluminum to the human bodies, can promote the growth of fingernails and hair, can promote the formation of antibodies and collagen, can maintain immune functions, can promote the synthesis of fat and protein, can maintain the completeness of blood vessels, can participate in the metabolism of phenylalanine, tyrosine and folic acid, can participate in the utilization of ferrum and carbohydrate by human bodies, can resist oxidation, can resist free radicals, and is good in mouth feel; the vitamin E collagen beverage is low in calorie, so that after drinking the vitamin E collagen beverage, people cannot gain weight due to accumulation of calorie; and the vitamin E collagen beverage can promote normal substance metabolism of the human bodies, so that the vitamin E collagen beverage is a healthy beverage.

An agent for suppressing elevation of blood GIP level, an agent for suppressing elevation of blood insulin level, an agent for lowering blood triglyceride level after meal ingestion and an agent for suppressing elevation of blood glucose level, these agents containing potassium polyglutamates as active ingredients.

A blood triglyceride depressant composition which comprises pravastatin and one or more members selected from the group consisting of (1) pantethine, (2) inositol hexanicotinate, (3) a combination drug containing a riboflavin compound, a tocopherol compound and an ascorbic acid compound, and (4) a combination drug containing a tocopherol compound and an ascorbic acid compound.

Nutritional fat or oil-based compositions for increasing HDL cholesterol, decreasing total cholesterol (TC), LDL cholesterol and decreasing the LDL / HDL cholesterol ratio in human plasma are described. The compositions can advantageously include at least 10% of myristic acid and / or lauric acid in which at least 3% of said fatty acid composition is myristic acid and at least 3% is lauric acid; in some cases at least 1% by weight myristic acid and / or lauric acid is esterified at the sn-2 position in triglyceride molecules. The compositions also include between 5% and 40% by weight linoleic acid, and typically further include at least 10% by weight monounsaturated fatty acids and between 15% and 55% by weight total saturated fatty acids. The sum of weight percentages for saturated, monounsaturated and polyunsaturated fatty acids equals 100%. In desirable cases, the composition is substantially cholesterol-free. Also described are fat compositions and diets which are adapted to limit increases in blood triglycerides, total cholesterol, LDL, and VLDL, even in the presence of dietary cholesterol.

This invention provides, a novel polyphenol compound having lipase inhibitory activity derived from tealeaves, a process for the preparation of the compound, and foods and / or beverages and pharmaceutical drugs containing the compound.Particularly, this invention provides a novel dimer compound of formula:obtained by oxidative polymerization of epigallocatechin-3-O-gallate, a main catechin component of oolong tea, with a tealeaf enzyme (polyphenol oxidase), as well as foods and / or beverages and pharmaceutical compositions containing said novel compound which suppress absorption of dietary lipids and suppresses increase of blood triglyceride.

The present invention provides a prophylactic and therapeutic agent for hyperlipidemia comprising a heterocyclic derivative represented by the following formula [1] or a medically acceptable salt thereof as an active ingredient, and a heterocyclic derivative represented by the formula [1] including The new compound: R 1 -Het-D-E [1] [wherein, R 1 represents an optionally substituted aryl group or an optionally substituted aromatic heterocyclic group. Het represents a divalent aromatic heterocyclic group. D represents an alkylene group, an alkenylene group, an alkynylene group, or the like. E represents carboxylic acid, etc.] The compound of the present invention has the effect of lowering blood triglycerides, lowering LDL-C, and lowering blood sugar. Therefore, it is effective in hyperlipidemia, arteriosclerosis, diabetes, hypertension and It is useful for the prevention or treatment of obesity and the like.

The present invention is related to an alcohol compound isolated from the extract of Cucurbitaceae family plant having anti-adipogenic and anti-obesity activity, and a composition comprising the same. The compound showed potent reducing activity of body weight, decreasing effect on the blood triglyceride and cholesterol level, activating activity of PPAR α and preventing activity from the adipogenesis of precursor fat cells with no toxicity, therefore, those extract can be useful in treating or preventing obesity and adipogenesis-involved diseases as a medicine or health care food.

The invention relates to an extended release nifedipine agent with sodium alginate as release materials and the components with the weight percentages: nifedipine 10 percent, sodium alginate 30 to 50 percent and the allowance of other medical supplemental materials. By adopting the sodium alginate as the only release materials, the invention has the advantages of strong controllability, stable storage, good efficacy, long control effect and less taking times for patients. As the sodium alginate is natural polysaccharide carbohydrate extracted from kelp, a natural cellulose, the invention not only reduces the side effect of the drugs but also alleviates the absorption of fatty acid and bile salt, thus having the effect of reducing the serum cholesterol, blood triglyceride and blood glucose; at the same time, the invention can prevent the accumulation of harmful metals such as strontium, cadmium and lead in intestinal of bodies and has the advantages of preventing diseases such as hypertension, diabetes mellitus and obesity, preventing sudden pathogenesis and safely spending pathogenesis peak periods.

The invention belongs to the field of animal genetic engineering and genetic modification, and in particular relates to the application of Abcg4 gene in constructing an animal model with two-way changes in obesity degree. The use specifically refers to constructing an animal model by knocking out the Abcg4 gene in an animal, or inhibiting the expression of the Abcg4 gene. The degree of obesity in the animal model is dependent on sex, as compared to wild-type littermates of the same sex, females become obese and blood triglyceride levels decrease, while males become lean and blood triglyceride levels increase. The model of the invention can be used to study obesity and related diseases, and can be used to screen out more effective and targeted drugs for treating obesity or treating elevated plasma triglycerides.

The present invention provides a preventive or therapeutic agent for hyperlipidemia, comprising as an active ingredient a heterocyclic compound of the formula Ä1Ü or a pharmaceutically acceptable salt thereof: R<1>-Het-D-E wherein: R<1> is optionally substituted aryl or aromatic heterocyclic group, Het is a divalent aromatic heterocyclic group, D is alkylene, alkenylene, alkynylene, or the like, and E is carboxy, or the like, and novel compounds among the heterocyclic compounds of the formula Ä1Ü above, which has blood triglyceride lowering effect, LDL-C lowering effect, and blood glucose lowering effect and blood insulin lowering effect, or HDL-C increasing effect or atherogenic index lowering effect all together, and hence is useful in the prevention or treatment of hyperlipidemia, arteriosclerosis, diabetes mellitus, hypertension, obesity, and the like.

There is provided a pharmaceutical composition for treatment or prevention of a neurodegenerative disease, comprising an RXR agonist as an active ingredient, which is a compound represented by formula (1) or (2). The pharmaceutical composition is effective in treatment or prevention of neurodegenerative diseases such as dementia, Parkinson's disease and multiple sclerosis with reducing side effects such as enlargement of the liver and elevation of blood triglyceride level. In these formulas, A represents CMe2, N-methyl, N-ethyl or N-isopropyl; X represents N, CH or C—CF3; Y and Z represent N or CH; R1 represents methyl, hydroxy, methoxy or ethoxy; R2 represents H, methyl or ethyl; B represents NR3 or CHR3; R3 represents alkyl; and R4 represents H, halogen, alkyl, alkenyl, aryl, alkynyl, alkoxy or acyl.