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41 results about "Heparan sulphate proteoglycan" patented technology

Methods and compositions based on inhibition of cell invasion and fibrosis by anionic polymers

The present invention relates to the discovery that biocompatible anionic polymers can effectively inhibit fibrosis, scar formation, and surgical adhesions. The invention is predicated on the discovery that anionic polymers effectively inhibit invasion of cells associated with detrimental healing processes, and in particular, that the effectiveness of an anionic polymer at inhibiting cell invasion correlates with the anionic charge density of the polymer. Thus the present invention provides a large number of materials for use in methods of inhibiting fibrosis and fibroblast invasion. Anionic polymers for use in the invention include but are not limited to natural proteoglycans, and the glycosaminoglycan moieties of proteoglycans. Additionally, anionic carbohydrates and other anionic polymers may be used. The anionic polymers dextran sulfate and pentosan polysulfate are preferred. In a more preferred embodiment, dextran sulfate, in which the sulfur content is greater than about 10% by weight, may be used. In a more preferred embodiment, the average molecular weight is about 40,000 to 500,000 Daltons. The present invention provides compositions and methods to inhibit fibrosis and scarring associated with surgery. The invention further provides compositions and methods to inhibit glial cell invasion, detrimental bone growth and neurite outgrowth. In a preferred embodiment, the inhibitory compositions further comprise an adhesive protein.
Owner:TRIAD

Water purifying agent for wastewater treatment of tire production enterprises and wastewater treatment method

The invention belongs to the technical field of environment-friendly water treatment, particularly relates to a water purifying agent for wastewater treatment of tire production enterprises and further relates to a method for treating wastewater of the tire production enterprises by adopting the water purifying agent. The water purifying agent contains an inorganic water purifying agent, a microbial water purifying agent and an enzyme preparation, wherein the inorganic water purifying agent is prepared from the ingredients in parts by weight: 5-20 parts of polyaluminum chloride, 4-16 parts of polyacrylamide, 2-15 parts of ferrous sulfate and 5-16 parts of aluminum sulfate; the microbial water purifying agent is prepared from the ingredients in parts by weight: 0.5-2.0 parts of nitrobacterium powder, 0.4-1.4 parts of paracoccus denitrificans powder, 0.2-0.8 part of thiobacterium powder and 0.3-1.2 parts of aniline degrading bacteria powder; the enzyme preparation is prepared from the ingredients in parts by weight: 0.1-1.5 parts of pectinase, 0.4-1.5 parts of cellulase, 0.1-0.8 part of dehydrogenase, 0.2-0.8 part of oxidoreductase and 0.1-0.6 part of xylanase. The water purifying agent and the method have the beneficial effects that by adopting the water purifying agent for wastewater treatment, disclosed by the invention, the water purifying effect is good, the water purifying speed is high, the safety is high, and no secondary pollution is caused; materials with adsorption capacity are used as raw materials and are assisted with microbes, so as to treat the wastewater, so that the range of use is wide, the transparency of treated water is extremely high, and recycling can be achieved.
Owner:肇庆市鼎湖区建翔环保技术有限公司

Sulfated fucan

InactiveUS20050255564A1Esterified saccharide compoundsSugar derivativesSulfationSulfated fucans
An enzyme capable of degrading sulfated fucan originating in a brown alga of Fucales which is useful in sugar chain engineering; a process for producing this enzyme; an oligosaccharide obtained by treating sulfated fucan with the enzyme; and production thereof.
Owner:TAKARA HOLDINGS

Optimized acid-resistant mannase MAN26gy as well as preparation method and application thereof

The invention provides optimized acid-resistant mannase MAN26gy and application thereof. 85-th-site amino acid leucine (L) in an amino acid sequence of mature mannase is modified into aspartic acid (D); 103-th-site amino acid asparaginate (N) is modified into aspartic acid (D). The optimal pH value of the modified mannase is 6.0 which is improved greater in comparison with the original mannase (the optimal pH value being 7.0); the acid resistance of the modified mannase is further improved, so that over 80% of the greatest enzyme activity between the pH values of 4.0 and 7.0 can be kept, and 70% of the greatest enzyme activity also can be kept when the pH value is 3.0. According to the invention, the enzymatic properties of the modified mannase are researched, so that greater experimental data is provided for enzyme application.
Owner:QINGDAO GENYUAN BIOLOGICAL TECH GRP

Fructus mori proteoglycan, and preparation method and application thereof

ActiveCN110016084AInhibit aggregationHas the effect of treating Alzheimer's diseaseNervous disorderPeptide/protein ingredientsDrugProteoglycan
The invention provides galacturonoglycan-containing protein polysaccharide FMP-6-S4 obtained from fructus mori, a preparation method of the protein polysaccharide FMP-6-S4, and applications of the protein polysaccharide FMP-6-S4 in preparation of medicaments for preventing and / or treating neurodegenerative diseases, inhibiting generation or aggregation of Abeta <42>, or inhibiting Alzheimer's disease. The protein polysaccharide FMP-6-S4 comprises 78-82% by weight of polysaccharide and 18-22% by weight of proteins, and the polysaccharide comprises galacturonic acid, galactose, arabinose, rhamnose and glucose. The protein polysaccharide FMP-6-S4 has a potential effect of treating Alzheimer's disease, and is expected to be developed into medicaments for treating Alzheimer's disease.
Owner:SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI

Landfill leachate sludge dewatering composite biological enzyme conditioner as well as preparation method and use method thereof

The invention relates to a landfill leachate sludge dewatering composite biological enzyme conditioner as well as a preparation method and a use method thereof. The conditioner comprises the following components in percentage by mass: 10-15% of cellulase; 5-8% of xylanase; 3-5% of laccase; 8-10% of pectinase; 12-18% of protease; 5-8% of chitosanase; 5-10% of lipase; 8-12% of fatty acid sorbitan; 10-15% of hexadecyl trimethyl bromide; 2-5% of sodium chloride; 1-3% of potassium sorbate; and 3-20% of deionized water. The components can be used for dewatering landfill leachate sludge after being mixed, extracellular polymeric substances in the sludge are extracted and damaged by the aid of the enzyme and the surfactant, so that water bound to the sludge is reduced, meanwhile, colloids and fine fibers in the sludge are modified and degraded by the conditioner, the filtering speed of water in the sludge is increased. The treated sludge is flocculated through a flocculating agent PAM, and finally, the dryness of the leachate sludge can be greatly improved through filter pressing and dewatering treatment, the dryness of the sludge after filter pressing can reach 55-65%, and the sludge can be directly incinerated together with garbage.
Owner:苏州埃斯腾特生物科技有限公司

Application of hydrogen-rich water composition in inhibition of hexavalent chromium-induced endoplasmic reticulum stress and autophagy in DF-1 cells

The invention discloses application of a hydrogen-rich water composition in inhibition of hexavalent chromium-induced endoplasmic reticulum stress and autophagy in DF-1 cells. The hydrogen-rich watercomposition comprises 0.6-1.1 mM of H2, 1.8-2.4 g / L of sodium alginate and 1.2-1.6 g / L of mannan. The hydrogen-rich water composition can maintain the stability of hydrogen content in hydrogen-rich water; moreover, the hydrogen-rich water composition can achieve an inhibition effect on the increase of the expression amount of COX-2 induced by Cr(VI) in the DF-1 cells, thereby inhibiting endoplasmic reticulum stress and excessive autophagy caused by the increase of COX-2 in the DF-1 cells.
Owner:山东德信生物科技有限公司
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