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A kind of sea velvet fucoidan sulfate and its application in the preparation of medicines and functional products for preventing and treating leukopenia

A technology of sea antler fucoidan sulfate and leukopenia, which is applied in the field of marine medicine, can solve the problems of high price and unsatisfactory curative effect, and achieve the effects of promoting proliferation, increasing the number of nucleated cells in bone marrow, and improving the formation of bone marrow

Active Publication Date: 2022-07-22
MARINE BIOMEDICAL RES INST OF QINGDAO CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the disadvantages of unsatisfactory curative effect and high price of drugs for treating leukopenia in the prior art, the present invention provides a kind of sea antler fucoidan sulfate and its use in the preparation of drugs and functional products for preventing and treating leukopenia. application

Method used

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  • A kind of sea velvet fucoidan sulfate and its application in the preparation of medicines and functional products for preventing and treating leukopenia
  • A kind of sea velvet fucoidan sulfate and its application in the preparation of medicines and functional products for preventing and treating leukopenia
  • A kind of sea velvet fucoidan sulfate and its application in the preparation of medicines and functional products for preventing and treating leukopenia

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Effect test

Embodiment 1

[0038] Embodiment 1, the preparation of sea velvet fucoidan sulfate (method 1)

[0039] Wash the sea velvet, dry it, crush it, and pass it through a 20-mesh sieve. Accurately weigh 200g of algal powder, add 2L of 0.05mol / L dilute hydrochloric acid according to the ratio of material to liquid 1:10, and extract at 60°C for 4h. The extract was centrifuged at 4000 rpm for 15 min, the supernatant was collected, and the algal residue was removed. The extraction supernatant was concentrated under reduced pressure to 1 / 5 of the total volume, and 95% ethanol was added to it until the ethanol concentration reached 20%, and the mixture was allowed to stand overnight to obtain a precipitated fraction HR-1. Continue adding 95% ethanol to the supernatant until the final concentration is 70%, let stand overnight, and dry the obtained precipitate in a 50° C. oven to obtain crude polysaccharide. The crude polysaccharide was prepared into an aqueous solution with a concentration of 2%, and af...

Embodiment 2

[0040] Embodiment 2, the preparation of sea velvet fucoidan sulfate (method 2)

[0041] Wash the sea velvet, dry it, crush it, and pass it through a 20-mesh sieve. Accurately weigh 200g of algal powder, add 0.1mol / L CaCl according to the ratio of material to liquid 1:20 22L, extracted at 70°C for 4h. The extract was centrifuged at 4000 rpm for 15 min, the supernatant was collected, and the algal residue was removed. The extraction supernatant was concentrated under reduced pressure to 1 / 5 of the total volume, and 95% ethanol was added thereto until the ethanol concentration reached 20%, and the mixture was allowed to stand overnight to remove the precipitate. Continue adding 95% ethanol to the supernatant until the final concentration is 70%, let stand overnight, and dry the obtained precipitate in a 50° C. oven to obtain crude polysaccharide. The crude polysaccharide was prepared into an aqueous solution with a concentration of 2%, which was classified by a 30kDa ultrafilt...

Embodiment 3

[0042] Embodiment 3, the preparation of sea velvet fucoidan sulfate (method 3)

[0043] Wash the sea velvet, dry it, crush it, and pass it through a 20-mesh sieve. Accurately weigh 200g of algae powder, add 2L of 0.2mol / L calcium chloride-0.05mol / L dilute hydrochloric acid mixed solution according to the ratio of material to liquid 1:10, and extract at 50°C for 4h. The extract was centrifuged at 4000 rpm for 15 min, the supernatant was collected, and the algal residue was removed. The extraction supernatant was concentrated under reduced pressure to 1 / 5 of the total volume, and 95% ethanol was added thereto until the ethanol concentration reached 30%, and the mixture was allowed to stand overnight to remove the precipitate. Continue adding 95% ethanol to the supernatant until the final concentration is 80%, let stand overnight, and dry the obtained precipitate in a 50° C. oven to obtain crude polysaccharide. The crude polysaccharide was passed through an anion exchange chrom...

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Abstract

The invention provides sea mushroom fucoidan sulfate and its application in the preparation of medicines and functional products for preventing and treating leukopenia. The present invention proves through cell experiments that the fucoidan sulfate can significantly promote the formation of granulocyte-macrophage hematopoietic progenitor cell colonies, and at the same time can promote the proliferation of bone marrow stromal cells. In vivo experiments further show that the fucoidan sulfate can significantly inhibit the decrease of leukocytes, neutropenia and thrombocytopenia in mice caused by cyclophosphamide, and increase the number of bone marrow nucleated cells in mice. The fucoidan sulfate provided in the present invention has the effect of antagonizing the myelosuppression caused by chemotherapeutic drugs, and can be used as a functional component for the development of drugs and functional products for preventing and treating leukopenia.

Description

technical field [0001] The invention belongs to the field of marine medicines, and in particular relates to sea velvet fucoidan sulfate and its application in the preparation of medicines and functional products for preventing and treating leukopenia. [0002] technical background [0003] Leukopenia is a common side effect of tumor radiotherapy and chemotherapy, which means that the number of leukocytes in the peripheral blood continues to be less than 4 × 10 9 pcs / L. If not treated in time, serious infection and complications may occur, which seriously threatens human health. Therefore, leukopenia caused by resistance to cancer therapy is a key factor to improve the quality of anticancer therapy. At present, the clinical drugs for the treatment of leukopenia mainly include granulocyte colony stimulating factor (G-CSF), granulocyte-macrophage colony stimulating factor (GM-CSF), adenine, squalane, etc. However, their application It is accompanied by high treatment costs or...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08B37/00A61P7/00
CPCC08B37/0063C08B37/0003A61P7/00
Inventor 胡婷赵峡于广利李建杰杨英杰管华诗辛萌李全才吕友晶
Owner MARINE BIOMEDICAL RES INST OF QINGDAO CO LTD
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