Food composition with effects of assisting blood fat reduction, weight loss and liver protection, and preparation method, preparation and application thereof

A technology for assisting blood lipid lowering and composition, applied in the field of functional food compositions, can solve the problems of complications, liver function damage, blood sugar rise, etc., and achieves reduction of fat absorption, reduction of liver index, and weight loss of intestinal flora. Effect

Active Publication Date: 2019-08-02
中国医科大学
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although these drugs have a good effect on lowering triglyceride and cholesterol, most of them will cause adverse reactions such as abdominal distension, nausea, and diarrhea. Some drugs can also cause blood sugar elevation and liver function damage.
At present, surgery, exercise and drugs are the main methods to treat obesity, but these treatment methods and methods often have complications

Method used

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  • Food composition with effects of assisting blood fat reduction, weight loss and liver protection, and preparation method, preparation and application thereof
  • Food composition with effects of assisting blood fat reduction, weight loss and liver protection, and preparation method, preparation and application thereof
  • Food composition with effects of assisting blood fat reduction, weight loss and liver protection, and preparation method, preparation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Embodiment 1: optimal prescription screening experiment

[0051] Prescription 1: a food composition with the functions of assisting blood fat reduction, weight loss and liver protection, which is composed of the following ingredients in parts by weight: 10 parts of hawthorn, 30 parts of lotus leaf, 5 parts of kudzu root, 5 parts of green tea, wolfberry fruit 5 parts, Poria cocos 3 parts, seabuckthorn 2 parts, celery powder 4 parts, mulberry leaves 3 parts, konjac powder 1 part, papaya 1 part, sealwort 1 part.

[0052] Prescription 2: a food composition with the functions of assisting blood fat reduction, weight loss and liver protection, which is composed of the following ingredients in parts by weight: 25 parts of hawthorn, 15 parts of lotus leaf, 10 parts of kudzu root, 6 parts of green tea, wolfberry 3 parts, Poria cocos 3 parts, seabuckthorn 2 parts, celery powder 1 part, mulberry leaves 3 parts, konjac powder 1 part, papaya 1 part, sealwort 1 part.

[0053] Recipe...

Embodiment 2

[0067] Example 2: Formulating prescriptions through literature search and big data analysis of network pharmacology

[0068] 【Experimental principle and method】

[0069]Network pharmacology is a new discipline developed on the basis of systems biology, proteomics, and genomics. Based on the understanding of the "drug-target-gene-disease phenotype" interaction network, the effects of drugs on diseases can be observed through network analysis. The intervention and influence of the drug will bring the drug development closer to the actual situation of the disease and improve the success rate of drug development. Traditional Chinese medicine is a complex system containing rich ingredients. Apply network pharmacology and bioinformatics to study the traditional Chinese medicine system, analyze the interaction between molecules-molecules, molecules-targets, and targets-diseases, and analyze the four major medicinal materials in the composition of the present invention. The component...

Embodiment 3

[0080] Example 3: Pharmacodynamic Evaluation of Optimal Prescription Auxiliary Lowering Blood Lipid and Weight Loss Effects

[0081] The optimal formula screened out in Example 1 was selected for pharmacodynamic evaluation to confirm its efficacy in assisting in lowering blood fat, losing weight, protecting liver and improving intestinal flora.

[0082] Optimal composition: a multifunctional food composition that assists in lowering blood fat, losing weight, protecting the liver and improving intestinal flora. 10 parts of green tea, 5 parts of medlar, 3 parts of poria cocos, 2 parts of seabuckthorn, 4 parts of celery powder, 2 parts of mulberry leaves, 1 part of konjac powder, 1 part of papaya, and 1 part of sealwort.

[0083] The preparation method of the composition is as follows: taking appropriate amount of each raw material, removing impurities, purifying, drying, pulverizing, passing through a 120-mesh sieve, and mixing the powder evenly for experimentation.

[0084] 【G...

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PUM

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Abstract

The invention relates to a food composition with the effects of assisting blood fat reduction, weight loss and liver protection. The food composition is prepared from the following raw materials in parts by weight: 20-25 parts of fructus crataegi, 20-25 parts of lotus leaf, 10-16 parts of radix puerariae, 10-18 parts of green tea, 4-6 parts of fructus lycii, 4-8 parts of poria cocos, 2-4 parts offructus hippophae, 1-3 parts of celery powder, 1-3 parts of folium mori, 1-2 parts of konjac powder, 1 to 3 parts of fructus chaenomelis lagenariae, and 1 to 2 parts of rhizoma polygonati. The prepared food composition can significantly reduce the body weight, fat/body ratio, food utilization rate and blood triglyceride, total cholesterol and low density lipoprotein cholesterol levels in a high fat model rat in the dosage range of each component, also can reduce the liver index, alanine aminotransferase and alkaline phosphatase levels in the high-fat model rat, can significantly increase the relative abundance of bacteroides and decrease the relative abundance of firmicutes, and has the clear effects of assisting blood fat reduction, weight loss, liver protection and intestinal flora improvement.

Description

technical field [0001] The invention belongs to the technical field of health food and medicine, and specifically relates to a functional food composition with the functions of assisting in lowering blood fat, reducing weight, protecting liver and improving intestinal flora. Background technique [0002] With the improvement of people's living standards and the change of living habits, dietary nutrition is enriched accordingly, and more and more high-fat, high-cholesterol and high-sugar foods are consumed, resulting in more and more hyperlipidemia and obese people, and increasingly younger age change. Hyperlipidemia (Hyperlipidemia, HLP) is a disease in which lipid metabolism disorders in the body lead to increased blood lipid levels. (VLDL), low-density lipoprotein (LDL) increased, and (or) high-density lipoprotein (HDL) decreased in a systemic lipid metabolism disorders. According to statistics, the prevalence of dyslipidemia in my country is 18.6%, the prevalence of hyp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8969A61P1/00A61P1/16A61P3/04A61P3/06A23L33/105
CPCA23V2002/00A61K36/076A61K36/185A61K36/23A61K36/488A61K36/605A61K36/62A61K36/732A61K36/734A61K36/815A61K36/82A61K36/888A61K36/8969A23L33/105A61P1/00A61P1/16A61P3/04A61P3/06A61K2300/00A23V2200/3262A23V2200/332A23V2200/32
Inventor 魏敏杰王宇王甜甜
Owner 中国医科大学
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