Nifedipine sustained release preparation and preparing method thereof

Abstract

The invention relates to an extended release nifedipine agent with sodium alginate as release materials and the components with the weight percentages: nifedipine 10 percent, sodium alginate 30 to 50 percent and the allowance of other medical supplemental materials. By adopting the sodium alginate as the only release materials, the invention has the advantages of strong controllability, stable storage, good efficacy, long control effect and less taking times for patients. As the sodium alginate is natural polysaccharide carbohydrate extracted from kelp, a natural cellulose, the invention not only reduces the side effect of the drugs but also alleviates the absorption of fatty acid and bile salt, thus having the effect of reducing the serum cholesterol, blood triglyceride and blood glucose; at the same time, the invention can prevent the accumulation of harmful metals such as strontium, cadmium and lead in intestinal of bodies and has the advantages of preventing diseases such as hypertension, diabetes mellitus and obesity, preventing sudden pathogenesis and safely spending pathogenesis peak periods.

Description

Nifedipine sustained-release agent and preparation method thereof technical field The invention relates to a medicine slow-release preparation for treating hypertension, in particular to a nifedipine slow-release preparation and a preparation method thereof. Background technique Because nifedipine can selectively inhibit the transmembrane transport of calcium ions into cardiomyocytes and smooth muscle cells, and inhibit the release of calcium ions from cells without changing the plasma calcium ion concentration, so among many calcium channel blockers, Nifedipine is recognized as a safe and effective drug because of its many clinical application studies, obvious antihypertensive effect, effective protection of target organs, and small toxic and side effects. The disadvantage of nifedipine is that the half-life is short (2.0 hours), and the patient needs to take the medicine frequently (taking medicine once every 4-6 hours). Because coronary heart disease and angina pectori...

AI Technical Summary

Problems solved by technology

The disadvantage of nifedipine is its short half-life (2.0 hours), and the patient needs to take it frequently (every 4-6 hours).

In recent years, domestic and foreign pharmaceutical companies have launched long-acting nifedipine successively. Because of its fast drug absorption, low peak blood concentration, long acting time and small side effects, it basically overcomes the shortcoming of short-acting nifedipine, but Most of its slow-release materials are non-ionic cellulose ethers made of natural polymer materials such as hypromellose and ethyl cellulose through a series of chemical processes. Although it is harmless to health, it is also not beneficial to the body.

It was published on September 28, 1994, and the publication number is CN1092649A, which discloses a technology of "nifedipine controlled-release tablet and its process method". The sustained-release material uses alginic acid and cellulose derivatives. Partially replaced cellulose derivatives. Due to the complicated process, in actual production, there are shortcomings in the process, such as large batch-to-batch differences and poor stability, and the quality is not easy to guarantee.