Salidroside sustained-release tablet and preparation method thereof

A technology for salidroside sustained-release tablets and salidroside sustained-release tablets, which are applied in the field of salidroside sustained-release tablets and their preparation, can solve the problems of inconvenient clinical medication and short half-life of patients, and reduce the occurrence of adverse reactions. efficiency, convenient operation, and the effect of reducing the number of times of use

Inactive Publication Date: 2011-11-30
NANJING JIZHONG MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Salidroside has a good anti-myocardial ischemia effect, but due to its short half-life in vivo, in order to maintain the effective blood concentration, it often needs to be used repeatedly in clinical practice, which brings inconvenience to the clinical use of patients

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Preparation of Salidroside Sustained Release Tablet 1

[0041] 1000 pieces

[0042] Salidroside 12g

[0043] Hypromellose (viscosity: 4000 centipoise) 15g

[0044] Hypromellose (viscosity: 100 centipoise) 30g

[0045] Lactose 150g

[0046] Magnesium Stearate 1g

[0047] Total weight 208g

[0048] Preparation:

[0049] Grind salidroside, hydroxypropylmethylcellulose (viscosity: 4000 centipoise), hydroxypropylmethylcellulose (viscosity: 100 centipoise) and lactose, pass through a 100-mesh sieve, and mix mechanically. Add 5% povidone aqueous solution (g / 100 ml, model: K30) to granulate during stirring, dry, and granulate. Then the dry granules after granulation are added with magnesium stearate dry powder, placed in a granulator, and mixed evenly. Punch the tablet with 8mm to get 1000 salidroside sustained-release tablets 1.

Embodiment 2

[0051] Preparation of Salidroside Sustained Release Tablet 2

[0052] 1000 pieces

[0053] Salidroside 8g

[0054] Hypromellose (viscosity: 4000 centipoise) 15g

[0055] Hypromellose (viscosity: 50 centipoise) 15g

[0056] Ethyl cellulose (viscosity: 20 centipoise) 15g

[0057] Lactose 150g

[0058] Magnesium Stearate 1g

[0059]

[0060] Total weight 204g

[0061] Preparation:

[0062] Grinding salidroside, hydroxypropyl methylcellulose (viscosity: 4000 centipoise), hydroxypropyl methylcellulose (viscosity: 50 centipoise), ethyl cellulose (viscosity: 20 centipoise), lactose, and passing 100 mesh sieve, mechanically mixed. During stirring, add 5% povidone (type: K30) aqueous solution to granulate, dry, and granulate. Then the dry granules after granulation are added with magnesium stearate dry powder, placed in a granulator, and mixed evenly. Punch the tablet with 8mm to get 1000 salidroside sustained-release tablets 2.

Embodiment 3

[0064] Preparation of Salidroside Sustained Release Tablet 3

[0065] 1000 pieces

[0066] Salidroside 24g

[0067] Hypromellose (viscosity: 4000 centipoise) 15g

[0068] Hypromellose (viscosity: 100 centipoise) 15g

[0069] Hypromellose (viscosity: 50 centipoise) 15g

[0070] 30g pregelatinized starch

[0071] Lactose 20g

[0072] Magnesium Stearate 1g

[0073]

[0074] Total weight 120g

[0075] Preparation:

[0076] Salidroside, hypromellose (viscosity: 4000 centipoise), hypromellose (viscosity: 100 centipoise), hypromellose (viscosity: 50 centipoise), pregelatin Grind starch and lactose, pass through a 100-mesh sieve, and mechanically mix. Add 5% povidone (type: K30) during stirring to granulate, dry, and granulate. Then the dry granules after granulation are added with magnesium stearate dry powder, placed in a granulator, and mixed evenly. 8mm punched tablet, get 1000 salidroside sustained-release tablets 3.

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Abstract

The invention provides a salidroside sustained-release tablet and a preparation method thereof. This slow-release tablet includes 2.0-60.00 parts by weight of salidroside, and 10.00-95.00 parts by weight of slow-release blocking material, wherein the slow-release blocking material includes: hydroxypropylmethylcellulose or hydroxypropylmethylcellulose Mixture with other cellulose. Its preparation method is to mix salidroside, slow-release retarding materials and fillers in the prescription amount of raw materials, add binders to make soft materials, granulate, dry, granulate, and granulate according to the conventional process of tablets. The dry granules after granulation are added with a lubricant, mixed evenly, and then compressed into tablets. The salidroside sustained-release tablet of the present invention can maintain a longer therapeutic effect after oral administration.

Description

technical field [0001] The invention relates to a slow-release preparation of drugs for treating cardiovascular diseases and a preparation method thereof, in particular to a salidroside sustained-release tablet and a preparation method thereof. Background technique [0002] Rhodiola is a plant of the genus Rhodiola (Rhodiola.L) in the Sedum family. It is a perennial herb or subshrub. It is mainly distributed in the Himalayas in the northern hemisphere, northwest Asia and North America, at an altitude of 1600-4000m. There are 96 species of rhodiola plants in the world, and 73 species in my country, which are mainly distributed in southwest, northwest, central, north and northeast China, especially in the alpine regions of Yunnan, Sichuan and Tibet. Salidroside (salidroside) is an active ingredient extracted from Rhodiola rosea. In recent years, pharmacological studies have shown that rhodiola has good cardiovascular effects, such as improving blood vessel effects, myocardial...

Claims

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Application Information

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IPC IPC(8): A61K9/22A61K31/7028A61K47/38A61P9/10
Inventor 李建宏李华
Owner NANJING JIZHONG MEDICAL TECH
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