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Use of crataegus pit extract in preparation of medicine for treating gastropathy

A technology of hawthorn core and extract, which is applied in the field of preparation and treatment of various stomach diseases caused by Helicobacter pylori, hawthorn core extract or its medicinal composition, which can solve the problems of coking at the bottom of the pot, and achieve convenience in taking and preparation. The method is simple and easy to promote

Inactive Publication Date: 2004-06-09
铁毅 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, if you start to heat up too quickly, it is easy to burn at the bottom of the pot

Method used

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Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0032] Experimental example 1 Observation on the effect of hawthorn core extract on anti-helicobacter pylorus in vitro

[0033] To detect the anti-Helicobacter pylori effect of three hawthorn core extracts in vitro.

[0034] Materials and Methods

[0035] 1. Drug samples to be tested

[0036] Three kinds of drug samples were tested: ① stock solution of distilled oil of hawthorn kernel; ② heavy stock solution of distilled oil of hawthorn kernel; Its preparation method is as follows respectively:

[0037] ①. Hawthorn core stock solution: refer to the method published in the 6th issue of "Chinese Medical Journal" in 1978. Before dry distillation, remove the soil and impurities on the hawthorn core, dry it in the sun, and set aside. After the dry distillation equipment is installed, put the hawthorn into the dry distillation pot Nuclei, about 80% of the pot body. Connect the oil outlet pipe and cooler. Asbestos cloth is used outside the retort to keep warm. Then, when the te...

experiment example 2

[0095] Experimental example 2. Therapeutic effect oral preparation of hawthorn nuclear distillate oil purification liquid

[0096] The oral preparation of 20% hawthorn distillate oil purification liquid, pH value 2.5-3.2 is a light yellow clear liquid, treating 30 patients with Helicobacter pylori infection, three times a day, 20ml each time, taking 14 consecutive days to treat Helicobacter pylori The clinical observation of bacterial infection has achieved relatively ideal results, as shown in Table 3:

[0097] Table 3. Observation on the effect of 20% hawthorn nuclear distillate oil on eradicating Helicobacter pylori in 30 cases:

[0098] Effect

[0099] Drug action time (days)

[0100] Eradication rate %

[0101] + -

[0102] 3 25 5 20%

[0103] 7 3 27 88.89%

[0104] 14 1 29 96.56%

[0105] Note: + means positive; - means negative.

Embodiment 1

[0107] The dry and clean hawthorn core is dry-distilled in the temperature range of 90-450°C, the dry distillation liquid obtained by condensation is rectified, and the distillate at 210-220°C is collected to obtain the stock solution of hawthorn seed distillate oil. Hawthorn core distilled oil stock solution is emulsified with emulsifier "RITAPRO100", and an appropriate amount of distilled water is added to prepare an oral solution with a content of 20% hawthorn core distilled oil stock solution.

[0108] Example: Hawthorn core distilled oil stock solution 20%;

[0109] Emulsifier RITAPRO100 15%;

[0110] Appropriate amount of seasoning;

[0111] Distilled water balance (add up to 100).

[0112] According to the above formula, the oral solution of hawthorn distillate oil stock solution with a concentration of 5-30wt% can also be prepared, wherein the emulsifier RITAPRO100 is used in an amount of 15-20wt%.

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Abstract

The present invention discloses hawthorn-pit extract or its medicinal composition and application of said medicinal composition in preparation of medicine for curing various gastropathies due to pyloric helicobacteria. Said invention uses the hawthorn-pit as raw material, and adopts the existent technological process including the steps of pyrogenic distillation and purification, etc. to obtain the invented hawthorn-pit distillate oil raw liquor. Said medicine is a pure natural product, its preparation process does not use any chemical substances, so that it has no any toxic side effects.

Description

technical field [0001] The invention relates to the use of hawthorn core extract in the preparation of medicines for treating stomach diseases, in particular to the use of hawthorn core extracts or pharmaceutical compositions thereof in the preparation of medicines for treating various stomach diseases caused by Helicobacter pylori, which belongs to the field of medicines. Background technique [0002] Helicobacter pylori is closely related to peptic ulcer and chronic gastritis, and Helicobacter pylori is a very important factor in the pathogenesis of fat ulcer and chronic gastritis. In patients with fat ulcer and chronic gastritis, the detection rate of Helicobacter pylori is above 80%. Once infected with Helicobacter pylori, if it is not cleared, it will carry the bacteria for life, and self-healing is extremely low. Therefore, the treatment of digestive system diseases must first eradicate Helicobacter pylori. [0003] Currently, only amoxicillin, clarithromycin, tetrac...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61P1/04A61P31/04
Inventor 铁毅刘民俐
Owner 铁毅
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