Application of isorhamnetin and its ramification in medication for treating tumor

A technology of isorhamnetin and tumor drugs, applied in the direction of anti-tumor drugs, drug combinations, medical preparations containing active ingredients, etc., can solve the problems of human body damage, large side effects, and ineffective tumors

Inactive Publication Date: 2004-08-11
王正荣 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing treatment methods often have the disadvantage of large side effects, and also cause a certain degree of damage to the human body in the process of treating tumors.
Most of the existing chemotherapy drugs have the disadvantages of high toxicity and great damage to healthy human cells
At the same time, due to the drug resistance of tumor cells and other reasons, the existing therapeutic drugs or methods are not very effective for some tumors.

Method used

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  • Application of isorhamnetin and its ramification in medication for treating tumor
  • Application of isorhamnetin and its ramification in medication for treating tumor
  • Application of isorhamnetin and its ramification in medication for treating tumor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0120]A kind of isorhamnetin medicine of the present invention, take isorhamnetin 200mg and add 1000ml physiological saline, heat in a water bath at 30°C, add 0.01M / L dilute NaOH solution to adjust the pH to 7.4 so that isorhamnetin is completely dissolved in physiological in salt water. The solution is sterilized and filtered and then filled to make isorhamnetin intravenous infusion. Intravenously infuse tumor patients at a dose of 5 mg / kg / day using an infusion device.

Embodiment 2

[0122] A kind of isorhamnetin derivative medicine of the present invention, weigh 50g of isorhamnetin glycosides, and mix with 250g of dry starch evenly. The powder is passed through a 120-mesh sieve twice, and mixed well. Then fill the empty capsules respectively. Make 1000 isorhamnetin capsules, each capsule containing isorhamnetin 50mg.

Embodiment 3

[0124] A kind of isorhamnetin medicine of the present invention, weigh 50g of isorhamnetin, mix with 250g dry starch. The powder is passed through a 120-mesh sieve twice, and mixed well. Then fill the empty capsules respectively. Make 1000 isorhamnetin capsules, each capsule containing isorhamnetin 50mg.

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Abstract

An application of isorhamnetin and its derivatives in preparing medicines for treating cervical cancer, liver cancer, squamous cell carcinoma of tongue, lung adenocar cinoma, etc is disclosed. Said isorhamnetin and its derivatives may be isorhammetin aglycone and isohamnoside. Its advantages are high curative effect, low toxic by-effect.

Description

technical field [0001] The invention relates to the application of isorhamnetin and its derivatives in medicine. Background technique [0002] Isorhamnetin is a known flavonoid. Isorhamnetin and its glycosides exist in many plants, such as seabuckthorn, dry willow, sage, gynostemma, camel thorn and wolfberry. It is very rich in seabuckthorn. Isorhamnetin has certain cardiovascular activities, such as anti-myocardial hypoxia-ischemia and anti-arrhythmia. It also has the effect of lowering serum cholesterol. Isorhamnetin is usually used as a standard to determine the content of flavonoids, but it has not been used in medicine. [0003] Tumor is a disease that seriously endangers human health. Its death rate ranks second in many countries, second only to cardiovascular diseases. The methods usually used to treat tumors are surgery, chemotherapy and radiotherapy. The existing treatment methods often have the disadvantage of large side effects, and also cause a certain degr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P35/00
Inventor 王正荣杨春蕾王跃锜屈艺
Owner 王正荣
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