Soft capsule of meat and bone meal of fur seal, preparation method and usage
A technology of fur dog meat and bone meal and fur dog meat, which can be used in medical formulas, medical preparations containing active ingredients, metabolic diseases, etc., and can solve problems such as poor calcium supplementation effect
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Embodiment 1
[0049] The present embodiment relates to the pharmaceutical test of the sea dog meat and bone powder capsule of the present invention 1. The toxicological safety evaluation test of the sea dog meat and bone powder capsule of the present invention
[0050] 1 Materials and methods
[0051] 1.1 Sample: Sea Dog Meat and Bone Meal Capsules, brown powder, packed in capsules. Its sea dog meat and bone meal capsules were used to conduct acute toxicity test in mice, polychromatic erythrocyte micronucleus test in mouse bone marrow, sperm abnormality test in mice, Ames test, and 30-day feeding test in rats.
[0052] 1.2 Experimental animals: Kunming white mice, provided by the Department of Experimental Animals, China Medical University, approval number: Liao Shi Dong Zhi Zi [2000] No. 015.
[0053] Wistar rats were provided by the Department of Experimental Animals, China Medical University, with the approval number: Liao Shi Dong Zhi Zi [2000] No. 015.
[0054] 1.3 Acute toxicity tes...
Embodiment 2
[0157] The raw materials of sea dog meat and bone meal capsules are: sea dog meat and bone meal, produced in Canada; calcium carbonate is natural calcium carbonate, produced by Zibo Xuena Industrial Co., Ltd.; empty capsules, produced by Boxing County Huifeng Gelatin Co., Ltd.
[0158] Mix 60% by weight of fur seal meat and bone meal and 40% by weight of calcium carbonate; then dry at 80°C for 12 hours, measure the water content to 3.31%, grind, pass through a 100-mesh sieve, and pack into capsules to obtain product. Each capsule is 500mg, and the recommended dosage is 3 times per person per day, 4 capsules each time, which is equivalent to 0.1g per kilogram of body weight (based on 60 kg body weight).
Embodiment 3
[0160] The raw materials of the sea dog meat and bone meal capsules are: sea dog meat and bone powder, produced in Canada; calcium carbonate is natural calcium carbonate, produced by Guilin Hongcheng Chemical Industry Co., Ltd.; empty capsules, produced by Qinghai Gelatin Co., Ltd.
[0161] Mix 70% by weight of fur seal meat and bone powder and 30% by weight of calcium carbonate; then dry at 60°C for 10 hours, measure the water content to 4.11%, grind, pass through a 120-mesh sieve, and pack into capsules to obtain product. Each capsule is 500mg, and the recommended dosage is 3 times per person per day, 4 capsules each time, which is equivalent to 0.1g per kilogram of body weight (based on 60 kg body weight).
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