Nicorandic drop pill and preparing method thereof

A nicorandil dropping pill and the technology of nicorandil, which are applied in the field of nicorandil dropping pills and its preparation, can solve the problem of affecting the therapeutic effect of nicorandil, low dissolution rate and dissolution rate, and large proportion of excipients and other problems, to achieve the effect of convenient carrying and taking, improved dissolution rate and dissolution rate, and reduced dosage of excipients

Inactive Publication Date: 2004-09-15
HONGYI SCI & TECH CO LTD NANCHANG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Nicorandil tastes bitter, slightly soluble in water, its tablet disintegration time is long, dissolution rate and dissolution rate are low, poor absorption, low bioavailability, large propo

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0051] prescription:

[0052] Nicorandil 5g

[0053] Macrogol 6000 15g

[0054] Makes 1000 capsules

[0055] Preparation method: Take the nicorandil fine powder that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten polyethylene glycol 6000 matrix, stir well, use simethicone oil as a coolant, make pellets by drop method, and dry. have to.

example 2

[0057] prescription:

[0058] Nicorandil 5g

[0059] Macrogol 4000 15g

[0060] Makes 1000 capsules

[0061] Preparation method: Take the nicorandil fine powder that has been superfinely pulverized and passed through a 200-mesh sieve, add it to the molten polyethylene glycol 4000 matrix, stir well, use simethicone oil as a coolant, make pellets by drop method, and dry. have to.

example 3

[0063] prescription:

[0064] Nicorandil 5g

[0065] Macrogol 6000 5g

[0066] Macrogol 4000 10g

[0067] Makes 1000 capsules

[0068] Preparation method: Take the nicorandil fine powder that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten polyethylene glycol 4000 and polyethylene glycol 6000 mixed matrix, stir well, use simethicone as the coolant, drop The preparation method is to make pills, dry them, and obtain them.

[0069] 4. Example 4

[0070] prescription:

[0071] Nicorandil 5g

[0072] Glyceryl monostearate 15g

[0073] Makes 1000 capsules

[0074] Preparation method: Take the fine powder of Nicorandil that has been superfinely pulverized and passed through a 200-mesh sieve, add it to the molten glyceryl monostearate base, mix well, use ice water as a coolant, make pellets by drop method, and dry to obtain .

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PUM

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Abstract

The present invention utilizes ultramicropulverization and dripping pill preparation production process to make nicorandil dripping pills, and can attain the goal of raising disintegration and dissolution speed, quickly obtaining therapeutic effect, raising production cost and convenient administration. Said pill not only can be sucked, but also can be swallowed, and its compliance property is good.

Description

technical field [0001] The invention relates to a pharmaceutical preparation and a preparation method thereof, in particular to Nicorandil dripping pills and a preparation method thereof. Background technique [0002] Nicorandil is an antiangina pectoris drug, which belongs to nitrate ester compound. It has the functions of preventing intracellular calcium ion dissociation, increasing the permeability of cell membrane to potassium ion, dilating coronary blood vessels, continuously increasing coronary blood flow, and inhibiting coronary artery spasm. The role of dilating coronary vessels does not affect blood pressure, heart rate, myocardial contractility and myocardial oxygen consumption. Nicorandil also has the effect of inhibiting platelet aggregation and preventing thrombosis. [0003] Nicorandil is absorbed quickly and completely when taken orally, with a bioavailability of 7.5%. 1 / 2 ) is about 1 hour. Mainly distributed in liver, heart, kidney, adrenal gland and bloo...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/4406A61P9/10
Inventor 钱进许军彭红李平朱丹刘孝乐
Owner HONGYI SCI & TECH CO LTD NANCHANG
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