Isatis root extract, and preparing method and use thereof

An isatis root extract and extract technology, which are applied in the fields of health care products, food and medicine, can solve the problems of many types of ingredients, low relative content of antiviral active components, and limited types of isatis root preparations, etc., and achieves simple operation and low production cost. Effect

Inactive Publication Date: 2004-09-15
GUANGZHOU BAIYUSN HUTCHISON WHAMPOA CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the research on the extraction process of Radix Isatidis above, the water extraction and alcohol precipitation process mentioned in "Chinese Pharmacopoeia" is simple, and there are many types of components in the obtained extract, and the relative content of antiviral active components is low, which leads to a large dose of Radix Radix Radix preparation, and at the same time It also limits the types of preparations of Radix Isatidis

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Take 100Kg of Radix isatidis medicinal material, decoct twice with 10 times the amount of water, the first time for 2 hours, the second time for 1 hour, and combine the decoction liquid. Filter, and the filtrate is concentrated to a fluid extract (1) with a relative density of 1.10 (50° C.), add 30 L of ethanol to the fluid extract (1), measure its ethanol concentration to be 70%, separate out a precipitate, and get the supernatant to concentrate To no alcohol smell, get extract (2) (code IsiL), extract (2) add 20L methanol-acetone mixed solvent to extract 3 times each time, the extract reclaims solvent, concentrates to get extract (3) (relative density 1.10), to obtain 8.6Kg active extract (numbering HG), which was determined to contain adenosine content of 2.56% (based on extract as dry product) by HPLC analysis. Concentrate the residue after methanol-acetone extraction, remove the methanol-acetone, and dilute with water to a certain concentration to obtain the sample...

Embodiment 2

[0033] "+" is lesion

[0034] The results show that the antiviral activity of the dry powder of Radix isatidis extract obtained in the invention is obviously stronger than that of the dry paste powder extracted by the original process.

Embodiment 3

[0036] medicine

[0037]The results showed that the newly prepared Isatidis granules and Isatidis tablets had stronger antiviral activity than the original Isatidis granules. The newly prepared Banlangen Granules and Banlangen Tablets have significant antiviral activity under the condition of low experimental concentration and high virus titer; while the original Banlangen Granules have antiviral effect only at high concentration and low virus titer. Only then is it obvious.

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PUM

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Abstract

The present invention relates to isatis root extract, its preparation method and its application, belonging to the field of medicine, food and health-care product. Said preparation method includes the following steps: making isatis root or crucifer isatis tinctoria undergo the processes of water extraction and alcohol precipitation treatment to obtain concrete, then using 10-50 times polar mixed solvent to make extraction to obtain extractive liquor, recovering solvent and concentrating to obtain its active extract. The determination shows that said extract contains lots of nucleoside with activity for resisting virus, its content is 5.2%-28.0%, its adenosine content is 1.10-2.80% (by dried extract product). Said extract can be used for preparing antiviral medicine, food and health-care product, can be made into granules, tablet, capsule preparation and solution preparation, etc.

Description

technical field [0001] The invention relates to a medicine derived from a plant raw material, a preparation method and an application thereof, belonging to the fields of medicine, food and health products, and in particular to an antiviral active ingredient of the traditional Chinese medicine Radix Radix and a preparation method thereof. Background technique [0002] Radix isatidis is the root of Isatis indigotica Fort., a cruciferous plant. It has the effects of clearing heat and detoxifying, cooling blood and relieving throat. "Chinese Pharmacopoeia" (1990-2000 edition) records the Radix Radix preparations such as Radix Radix Radix Granules and the extraction process of Radix Radix Radix Radix Isatidis granule and Radix Radix Radix is ​​all to take the water decoction of Radix Radix Radix and add ethanol to make its concentration 60%. Made from accessories. There are also literature reports on the research on the extraction process of Radix Radix Radix, "Isatidis Radix An...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/105A61K31/7076A61P31/12
Inventor 李楚源曾令杰陈矛
Owner GUANGZHOU BAIYUSN HUTCHISON WHAMPOA CHINESE MEDICINE
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