Coating material for leukocyte removal filter and the filter material

A filter and white blood cell technology, applied in the polymer field, can solve the problems that cannot be said about the ability to remove white blood cells and platelets, adequately, and deal with pressure rise.

Inactive Publication Date: 2004-11-10
ASAHI KASEI MEDICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, if the zeta potential is increased in order to increase the leukocyte adsorption capacity, there is a general tendency to see not only the leukocyte and platelet adsorption but also the red blood cell adsorption, the process pressure rises, and the leukocyte-removing ability of the filter decreases over time.
In addition, in order to avoid the pressure rise of the filter, countermeasures such as disposing the main filter material with a negative zeta potential on the upper layer are mentioned, aiming at suppressing the adsorption of leukocytes and platelets in the upper layer, although it is possible to suppress the pressure of the entire treatment time and reduce the leukocyte Leakage, but it cannot be said that the ability to remove leukocytes and remove platelets is sufficient

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0117] Using ethanol as a polymerization solvent, the ethanol solution in which the above-mentioned polymerizable monomer and diazo initiator were dissolved was dropped while stirring at 78° C. in a nitrogen atmosphere to perform polymerization. Each polymerizable monomer added is methyl methacrylate (hereinafter referred to as MMA) 3mol%, dimethylaminoethyl methacrylate (hereinafter referred to as DM) 6mol%, dihydroxyethyl methacrylate ( Hereinafter referred to as HEMA) 91 mol%. The polymerization solution was refined in excess water and dried under reduced pressure. pass 1 The copolymerization composition of the polymer was determined by H-NMR. As a result, the copolymerization composition of MMA in the polymer was 3 mol%, the copolymerization composition of DM in the polymer was 6 mol%, and the copolymerization composition of HEMA in the polymer was 91 mol%, which was almost the same as the addition ratio. (hereinafter referred to as HAM036). The weight average molecula...

Embodiment 2

[0119] The addition ratio of each polymerizable monomer is 5 mol% of MMA, 6 mol% of DM, and 89 mol% of HEMA. Polymerization, purification, and drying are carried out under the same conditions as in Example 1. pass 1 The copolymerization composition of the polymer was determined by H-NMR. The copolymerization composition of MMA in the polymer was 5 mol%, the copolymerization composition of DM in the polymer was 6 mol%, and the copolymerization composition of HEMA in the polymer was 89 mol%. (hereinafter referred to as HAM056). The weight average molecular weight Mw was 300,000. Using ethanol as a coating solvent, at a concentration of 1w / v%, the specific surface area of ​​the raw material is 1.47m 2 / g, porosity 86%, average fiber diameter 1.2μm, average pore diameter 6.3μm, 40g / m 2 Sixteen polyester nonwoven fabrics were coated. Its retention, the total surface of the filter material per unit area is 12mg / m 2 . The evaporation residue was determined to be below 0.1 mg. ...

Embodiment 3

[0121] The addition ratio of each polymerizable monomer is 30mol% of MMA, 6mol% of DM, and 64mol% of HEMA. Polymerization, purification and drying are carried out under the same conditions as in Example 1. pass 1 The copolymerization composition of the polymer was determined by H-NMR. The copolymerization composition of MMA in the polymer was 30 mol%, the copolymerization composition of DM in the polymer was 6 mol%, and the copolymerization composition of HEMA in the polymer was 64 mol%. (hereinafter referred to as HAM306). The weight average molecular weight Mw was 240,000. Using ethanol as a coating solvent, at a concentration of 1w / v%, the specific surface area of ​​the raw material is 1.47m 2 / g, porosity 86%, average fiber diameter 1.2μm, average pore diameter 6.3μm, 40g / m 2 Sixteen polyester nonwoven fabrics were coated. Its retention, the total surface of the filter material per unit area is 12mg / m 2 . The evaporation residue was determined to be below 0.1 mg. T...

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Abstract

It is intended to provide a polymer for coating a leukocyte removal filter material which is excellent in the capability of removing leukocytes. It is further intended to provide a filter whereby both of leukocytes and platelets can be highly efficiently removed from a blood product containing leukocytes and platelets. The above objects can be achieved by using a polymer for coating a leukocyte removal filter material which comprises a unit originating in a hydrophobic polymerizable monomer, a unit originating in a polymerizable monomer containing a basic nitrogen-containing part, and a unit originating in a polymerizable monomer containing a protonic neutral hydrophilic part.

Description

technical field [0001] The present invention relates to a polymer for coating a leukocyte-removing filter raw material, and a leukocyte-removing filter material containing the novel polymer on its surface. In particular, the present invention relates to a polymer suitable for coating a filter for efficiently removing leukocyte contamination causing side effects during blood transfusion from a blood preparation for blood transfusion, and a leukocyte-removing filter material containing the novel polymer on its surface. In addition, the present invention also relates to a filter material capable of efficiently removing leukocytes and platelets that cause side effects during blood transfusion at the same time. Background technique [0002] In recent years, in the field of blood transfusion, blood transfusion after removal of leukocytes contained in blood preparations, that is, so-called leukocyte-depleted blood transfusion, has been gradually carried out. This is because it has...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/14A61K35/18A61M1/34C08F220/26C12N5/00C12N5/078
CPCC12N5/0087C12N5/0634A61M1/3633B32B5/022B32B27/308B32B27/36A61M2202/0439A61P7/00C08F220/12
Inventor 八木康彦三浦裕文
Owner ASAHI KASEI MEDICAL CO LTD
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