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Prognostic indicator

An indicator and prognostic technology, applied in the direction of antibody medical components, peptide sources, instruments, etc., can solve problems such as the inability to clarify the role of OPN

Inactive Publication Date: 2004-12-08
UNIV OF LIVERPOOL
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  • Summary
  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0017] Although major work is related to the presence of OPN in cancer cells, the role of OPN in cancer (in general) or (in particular) metastasis has not yet been elucidated

Method used

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Embodiment Construction

[0043] figure 1 with figure 2 Shows Kaplan Meier survival curves for surgically resected breast cancer tissue from a cohort of 339 patients with primary cancer in operable stages I and II disease, from the Merseyside area, at the Royal University in 1976-1982 Hospital diagnosis (Winstanley et al., 1991, Br J Cancer 63:447-450; 1993, Br J Cancer 67:762-772). The age range was 29-92 years (average 57 years). Specimens were routinely fixed in neutral buffered formalin and preserved in paraffin blocks. Follow-up information on patient survival was obtained and updated to August 31, 1995. Anti-osteopontin (alphaMBIII Bio(1)) was obtained from the Development Studies Hybridoma Bank of Iowa State University, a monoclonal mouse antibody of the IgG1 isotype, and was used at a 1 / 30 dilution in PBS containing 0.05% BSA. The second antibody was a biotinylated sheep anti-mouse antibody (Amersham, Bucks) diluted 1 / 200 in PBS containing 0.5% BSA. Antibodies were developed with ABC comp...

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Abstract

A prognostic indicator for metastasis comprises an antibody directed against ostepontin.

Description

field of invention [0001] The present invention relates to a metastasis prognosis indicator, a vaccine against metastasis, a method of treating metastasis, and a kit for diagnosing life-threatening metastasis. Background of the invention [0002] Most cancers are thought to be due to changes in specific genes, either mutations that make their gene products more effective in a certain way, or overexpression of normal genes that make their effects stronger. These oncogenes have essentially been identified by introducing gene-length fragments of human cancer DNA into mouse fibroblast cell lines, culturing, and selecting those cell lines that grow in an uncontrolled manner in liquid or semi-solid media . The oncogene itself was isolated by cloning human DNA fragments from mouse DNA using standard recombinant techniques. In addition, mutations can also occur in genes that suppress the activity of oncogenes (such as P53 or Rb) or genes that suppress the level of their products (...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7088A61K39/00A61K39/39A61K39/395A61K45/00A61P35/00A61P35/04C07K14/47C07K16/18C12N15/09G01N33/53G01N33/574
CPCA61K39/0011G01N2333/52G01N33/57484A61K2039/55566A61P35/00A61P35/04A61K2039/812
Inventor A·J·史密斯P·S·鲁德兰德
Owner UNIV OF LIVERPOOL
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