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Light stabilized antimicrobial materials

An antibacterial activity, hydrophilic technology, applied in the direction of antibacterial drugs, synthetic active ingredients of polymeric materials, medical preparations containing active ingredients, etc. question

Inactive Publication Date: 2005-01-19
CONVATEC TECH INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

While ammonium solutions are reported to increase the concentration of silver that can be incorporated into the dressing, photostability is not mentioned and it is not possible to improve photostability

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0018] We have found that silver can be stabilized in polymers used in medically related materials. The advantage is that the material exhibits antimicrobial activity while not being prone to photodegradation or light sensitivity. This photostable medical material is particularly suitable for use in wound dressings, which create a moist wound repair environment, especially for moderately or heavily exuding wounds such as chronic or acute wounds. Other medical materials that may benefit from the methods described herein include ostomy products, ostomy appliances, or other medical materials exposed to possible sources of infection.

[0019] The present invention thus provides a method of preparing materials comprising one or more hydrophilic, amphoteric or anionic polymers, wherein the polymers possess antimicrobial activity. Preferably the material comprises a polymer useful in medical devices, wound dressings or ostomy devices. Materials particularly suitable for use in the ...

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PUM

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Abstract

Methods of enhancing the photostabilizing of silver in medical materials are described. More particularly, the methods increase the photostabilization of silver in certain materials comprising hydrophilic, amphoteric and anionic polymers by subjecting the polymers to solutions containing an organic solvent and silver, during or after which one or more agents are added which facilitate the photostablization of the material.

Description

[0001] This application claims priority to US Provisional Application No. 60 / 250,182, filed December 29, 2000, the entire contents of which are incorporated herein by reference. technical field [0002] The present invention relates to photostable antimicrobial materials and methods of preparing antimicrobial polymers for use in wound dressings and medical devices. Background technique [0003] Infection is a problem associated with trauma. Infection can hinder trauma recovery in traumatized patients and can greatly increase the cost and time of treatment. There is therefore a need to both prevent and treat infections resulting from trauma or wounds associated with wound dressings or the use of other medical devices. Examples of these potentially hazardous devices include prosthetic devices, grafts, or wound dressings for acute or chronic secretory wounds. This problem can be addressed by the use of topical antiseptics. [0004] It is known to include antimicrobial agents...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L2/16A61K31/28A61K31/74A61K33/38A61L15/16A61L15/44A61L26/00A61L27/54A61L29/16A61L31/00A61L31/16
CPCA61L2300/404A61K33/38A61L2300/102A61L29/16A61L15/44A61K31/74A61L2300/45A61L2300/104A61L27/54A61K31/28A61L31/16A61L26/0066A61P13/00A61P31/04A61K2300/00
Inventor P·鲍勒E·亚克奎斯D·帕森斯
Owner CONVATEC TECH INC