Method and apparatus for measuring concentration of blood sampler special component

Abstract

The present invention relates to specific component in a blood specimen containing a blood corpuscle, such as consistency measurement technology of glucose. In the present invention, to calculate the consistency of the specific component in consideration of the diffusion speed of the specific component diffused to the outside of the blood corpuscle from the inside thereof. Under ideal condition, the diffusion speed is showed as a Michaelis-Menten equation: V = V [max] delta S / ( K [m] + delta S), wherein V [max] is potential maximum film permeance speed of the specific component from the blood corpuscle to outside, K [m] is michalis constant (the value of delta S when V = V [ max ] /2), delta S is the consistency difference between the inner and outer of the specific components of the blood corpuscle.

Description

technical field [0001] The invention relates to a technique for measuring the concentration of specific components of blood samples containing blood cells, such as glucose. Background technique [0002] There is a method called the electrode method to measure a specific component in a blood sample, such as glucose concentration. In this method, information on the glucose concentration in the blood sample is output to electrodes in contact with the blood sample, and the glucose concentration is calculated from the output value. The electrode method is broadly classified into an equilibrium point method (endpoint method) and a differential method (rate method). The equilibrium point method calculates the glucose concentration based on the equilibrium value when the output from the electrodes tends to a certain value over time. And the differential method calculates the glucose concentration according to the maximum value after the output value is differentiated n times (n is...

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Problems solved by technology

[0005] However, any of the above methods only attribute poor measurement accuracy to blood cell density

As a result, in the prior art, when the glucose concentration in the blood is low (for example, 400 mg / dL), the degree of correlation when measuring the glucose concentration using plasma (or serum) is high

However, when the glucose concentration in the blood is high (for example, 500mg / dL), the degree of correlation is low when using plasma (or serum) to measure the glucose concentration, and the measured value tends to be low

Therefore, in terms of the measurement accuracy and measurement range of the high concentration area in the above method, there is still room for improvement.

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