Combination of Chinese traditional medicine for treating disease of liver and preparation method

A technology of liver disease and composition, applied in the field of medicine

Inactive Publication Date: 2005-08-31
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In the current research on Tianjihuang medicinal materials and Tianjihuang injection, there are no research reports and patent applications about the separation and purification of effective parts and monomers from Tianjihuang for active screening of liver disease treatment; the present invention aims at The hepatoprotective activity of Tianjihuang, under the tracking guidance of pharmacological activity screening, was isolated and purified from Tianjihuang, the effective part of hepatoprotection, anti-hepatitis, and anti-liver fibrosis-Tianjihuang total flavonoids, and isolated from it Four main monomer compounds were identified: quercitrin, isoquercitrin, Tianjihuangdixanthone C and Tianjihuangdixanthone D, among which Tianjihuangdixanthone C and Tianjihuangdixanthone D were discovered for the first time new compounds of

Method used

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  • Combination of Chinese traditional medicine for treating disease of liver and preparation method
  • Combination of Chinese traditional medicine for treating disease of liver and preparation method
  • Combination of Chinese traditional medicine for treating disease of liver and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0071] Example 1: 5.0Kg of Tianjihuang dried medicinal material, reflux extraction with 50 liters of 60% ethanol solution for 2 times, each time for 2 hours, combined two extracts, concentrated under reduced pressure to obtain 620g of extract, dispersed with 2 liters of water, adjusted When the pH value reaches 5-6, extract three times with 30 liters of ethyl acetate, combine the three extracts, add anhydrous sodium sulfate for dehydration, filter through 0.45 μm, and concentrate the filtrate to dryness under reduced pressure to obtain 120 grams of total flavonoids of Tianjihuang .

Embodiment 2

[0072] Embodiment 2: Take 10 g of the above-mentioned total flavonoids composition of Tianji Huang, mix it with 50 g of silica gel, add it to the top of the installed silica gel column, elute with chloroform: methanol system gradient, track by TLC, and combine chloroform: methanol ( 15:1, 5:1) fractions were purified by column chromatography to obtain 0.4 g of xanthanone C, 0.7 g of xanthone D, 3.6 g of quercitrin and 4.7 g of isoquercitrin.

Embodiment 3

[0074] Tablet: Tianjihuang Total Flavonoids 60g

[0075] Lactose 187g

[0076] Cornstarch 50g

[0077] Magnesium Stearate 3g

[0078] Preparation method: mix total flavonoids of Tianjihuang, lactose and starch, moisten it evenly with water, sieve the wetted mixture and dry it, then sieve it, add magnesium stearate, then press the mixture into tablets, each tablet weighs 300mg, The total flavonoid content of Tianjihuang is 60mg.

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Abstract

A Chinese medicine for treating hepatism is prepared from the Herba Hyperici Japonici through extracting in alcohol, concentrating, regulating pH value, and extracting by ethyl acetate.

Description

technical field [0001] The invention relates to the technical field of medicine, and relates to a traditional Chinese medicine composition for treating liver diseases and a preparation method thereof. Background technique [0002] Hepatitis is one of the most serious infectious diseases in the world, and it is closely related to the occurrence of liver cancer. According to the statistics of the World Health Organization, at present, there are about 350 million people in the world suffering from chronic hepatitis or asymptomatic virus infection. These chronic hepatitis patients have a high risk of turning into liver cirrhosis and liver cancer. Every year, more than 1 million people die from diseases related to hepatitis, liver cirrhosis and liver cancer. my country is an area with a high incidence of hepatitis. According to statistics, 90% of liver cancer patients have a background of hepatitis virus infection, and currently liver cancer has taken the second place in tumor m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K9/19A61K9/20A61K9/48A61P1/16
Inventor 张卫东傅芃李慧梁张川苏娟柳润
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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