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Compound cefaclor dispersible tablet

A technology of cefaclor and dispersible tablets, applied in the direction of pill delivery, antibacterial drugs, etc., to achieve the effects of high production industrialization, high bioavailability, and convenient taking and carrying

Inactive Publication Date: 2005-09-14
黄本东
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no scattered supply of compound cefaclor at home and abroad

Method used

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Embodiment Construction

[0030] According to the preparation method disclosed in the description, the present invention has prepared 15 formulas as shown in Table 1. The specific excipients and dosage are shown in Table 1. See Table 1 for the results of detecting its dispersibility according to the method of Chinese Pharmacopoeia (2000 edition).

[0031] The result shows that the compound cefaclor dispersible tablet provided by the invention meets the regulations of the Chinese Pharmacopoeia (2000 edition) about dispersible tablets.

[0032] Example

[0033] Raw materials

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PUM

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Abstract

The invention relates to a new drug from of cefaclor belonging to heavy oral cephalosporin antibacterial drugs, comprising following compositions in weight fractions: cefaclor is 250 deals in non water cefaclor; bromhexine hydrochloride is 8.77 deals in bromhexinum; filling agent is 0-140 deals selected from lactose, white dextrine, starch or / and compressible starch; diluent is 30-140 deals selected from microcrystalline cellulose; disintegrating adminicle is 20-150 deals selected from L-HPC or / and crospovidone; lubricating agent is 7-15 deals selected from micropowder silica gel or / and magnesium. The compound cefaclor dispersible tablet provided can disintegrate quickly in the body, improve its dissolution, promote absorption, and have high bioavailability.

Description

technical field [0001] The invention relates to a new dosage form of powerful oral cephalosporin antibacterial drug cefaclor. technical background [0002] Compound cefaclor is composed of cefaclor, a powerful oral cephalosporin antibacterial drug, and bromhexine hydrochloride, a powerful antitussive and expectorant component. The combination of the two drugs produces a synergistic effect, which can quickly relieve and cure the symptoms of respiratory tract infection. A good medicine with good curative effect, low side effect and convenient use. [0003] Cefaclor is a broad-spectrum semi-synthetic cephalosporin antibiotic. The activity against penicillinase-producing Staphylococcus aureus, group A hemolytic streptococcus, viridans streptococcus and staphylococcus epidermidis is the same as that of cefadroxil, and the antibacterial effect against non-enzyme-producing staphylococcus aureus and pneumococcus is higher than that of cefadroxil 2 to 4 times stronger. The activit...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/545A61P31/04
Inventor 郑南芝邓君玲
Owner 黄本东
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