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Chinese medicinal preparation for dilating coronary artery and preventing from platelet aggregation

An anti-platelet aggregation and coronary artery technology, applied in pharmaceutical formulations, medical preparations containing active ingredients, blood diseases, etc., can solve problems such as affecting clinical treatment effects, difficult quality control, etc. stored effect

Inactive Publication Date: 2005-10-12
王衡新
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Existing Shenxiong injection is easily affected by various factors such as production and storage, and its quality is difficult to control, which affects the clinical treatment effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Take 200g of Salvia miltiorrhiza, extract it with water and treat it with stone sulfur method, then use alcohol precipitation twice, the first time make the alcohol content reach 60%, the second time make the alcohol content reach 70%, recover the ethanol, and make the alcohol content per 1ml The clear liquid of Salvia miltiorrhiza 4g is used to adjust the PH value as a backup liquid. Mix 20g of ligustrazine hydrochloride, 200ml of glycerin and the above liquid medicine evenly, add water for injection, adjust PH with hydrochloric acid, cool and let it stand for a total of 1000ml, add activated carbon, stir well, boil for 10 minutes, cool and filter, add appropriate amount of water for injection , subpackaged, dried, and capped to obtain a powder-injection product, or freeze-dried and capped, to obtain a freeze-dried powder-injection product.

Embodiment 2

[0016] Take 200g of Salvia miltiorrhiza, extract it with water and treat it with stone sulfur method, then use alcohol precipitation twice, the first time make the alcohol content reach 60%, the second time make the alcohol content reach 70%, recover the ethanol, and make the alcohol content per 1ml The clear liquid of Salvia miltiorrhiza 4g is used to adjust the PH value as a backup liquid. Mix 20g of ligustrazine hydrochloride, 200ml of glycerin and the above medicinal solution, add water for injection, adjust the pH with hydrochloric acid, cool and let it stand, and make a total of 1000ml, add 0.1% sodium bisulfite or sodium pyrosulfite or a mixture of the two for stabilization Use 3% mannitol as a supporting agent, stir to make it dissolve completely, then add 0.05% activated carbon for treatment, filter to obtain a pyrogen-free clear solution, subpackage, dry, and press the cap to obtain powder injection products; freeze-dry, press Cover to obtain the freeze-dried powder ...

Embodiment 3

[0018] Take 200g of Salvia miltiorrhiza, extract it with water and treat it with stone sulfur method, then use alcohol precipitation twice, the first time make the alcohol content reach 60%, the second time make the alcohol content reach 70%, recover the ethanol, and make the alcohol content per 1ml The clear liquid of Salvia miltiorrhiza 4g is used to adjust the PH value as a backup liquid. Mix 20g of ligustrazine hydrochloride, 200ml of glycerin and the above medicinal solution, add water for injection, adjust the pH with hydrochloric acid, cool and let it stand, and make a total of 1000ml, add 0.05% sodium bisulfite or vitamin C or a mixture of the two, or Fill with nitrogen as a stabilizer, then add 3% dextran as a support agent, stir to dissolve it completely, then add 0.05% activated carbon for treatment, filter to obtain a clear solution without pyrogen, subpackage, dry, and press the cap to obtain powder injection Products; freeze-drying, capping, and freeze-dried powd...

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PUM

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Abstract

A Chinese medicine in the form of injection for treating and preventing thrombocyte coagulation and dilating arteria coronaria is prepared from red sage root, liqustrazine hydrochloride, glycerine, and water for injection. Its preparing process is also disclosed.

Description

Technical field: [0001] The invention relates to a traditional Chinese medicine injection and a production process thereof, in particular to a Shenxiong powder injection or freeze-dried powder injection for injection and a preparation method thereof. Background technique: [0002] Powder injection or freeze-dried powder injection is a pharmaceutical dosage form, and according to the relevant regulations on drug management in my country, changing the dosage form is managed as a new drug research. Shenxiong original injection, and included in the national drug standards. [0003] The existing traditional Chinese medicine injection for anti-platelet aggregation and coronary artery expansion is a kind of Shenxiong injection, which is made by extracting Danshen with water, treating it with lime sulfur, ethanol-precipitating the filtrate twice, and recovering ethanol. The clear liquid containing 4g of medicinal materials, adjust the pH value, add ligustrazine hydrochloride and gl...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K9/19A61P7/02A61P9/10
Inventor 王衡新
Owner 王衡新
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