Chinese medicinal preparation for dilating coronary artery and preventing from platelet aggregation

An anti-platelet aggregation and coronary artery technology, applied in pharmaceutical formulations, medical preparations containing active ingredients, blood diseases, etc., can solve problems such as affecting clinical treatment effects, difficult quality control, etc. stored effect

Inactive Publication Date: 2005-10-12
王衡新
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Existing Shenxiong injection is easily affected by various factors such as production an

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0013] Example one:

[0014] Take 200g of Salvia miltiorrhiza after water extraction and treatment with lime sulfur method, and then use alcohol precipitation twice, the first time to make the alcohol content reach 60%, the second time to make the alcohol content reach 70%, and the ethanol is recovered to make the content per 1ml. 4g of salvia miltiorrhiza is a clear liquid to adjust the PH value and use it as a backup medicinal solution. Mix 20g of ligustrazine hydrochloride, 200ml of glycerin and the above medicinal solution, add water for injection, adjust the pH with hydrochloric acid, cool and stand to make a total of 1000ml, add activated carbon, stir evenly, boil for 10 minutes, cool and filter, add appropriate amount of water for injection , Divide, dry, and press to obtain the powder injection product, or freeze-dry and press the cover to obtain the freeze-dried powder injection product.

Example Embodiment

[0015] Embodiment two:

[0016] Take 200g of Salvia miltiorrhiza after water extraction and treatment with lime sulfur method, and then use alcohol precipitation twice, the first time to make the alcohol content reach 60%, the second time to make the alcohol content reach 70%, and the ethanol is recovered to make the content per 1ml. 4g of salvia miltiorrhiza is a clear liquid to adjust the PH value and use it as a backup medicinal solution. Mix 20g of ligustrazine hydrochloride, 200ml of glycerin and the above medicinal solution, add water for injection, adjust the pH with hydrochloric acid, cool and stand to make a total of 1000ml, add 0.1% sodium bisulfite or sodium metabisulfite or a mixture of both for stability Use 3% mannitol as a support agent, stir to dissolve it completely, add 0.05% activated carbon, filter to obtain a clear solution without heat source, pack, dry, and press to obtain the powder injection product; freeze-drying, pressing Cover to obtain freeze-dried pow...

Example Embodiment

[0017] Embodiment three:

[0018] Take 200g of Salvia miltiorrhiza after water extraction and treatment with lime sulfur method, and then use alcohol precipitation twice, the first time to make the alcohol content reach 60%, the second time to make the alcohol content reach 70%, and the ethanol is recovered to make the content per 1ml. 4g of salvia miltiorrhiza is a clear liquid to adjust the PH value and use it as a backup medicinal solution. Mix 20g of ligustrazine hydrochloride, 200ml of glycerin and the above medicinal solution, add water for injection, adjust the pH with hydrochloric acid, cool and stand to make a total of 1000ml, add 0.05% sodium bisulfite or vitamin C or a mixture of both, or Fill with nitrogen gas as a stabilizer, add 3% dextran as a support agent, stir to dissolve it completely, add 0.05% activated carbon to process, filter to obtain a clear solution without heat source, pack, dry, and press to obtain a powder injection Products: freeze-drying and pressin...

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PUM

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Abstract

A Chinese medicine in the form of injection for treating and preventing thrombocyte coagulation and dilating arteria coronaria is prepared from red sage root, liqustrazine hydrochloride, glycerine, and water for injection. Its preparing process is also disclosed.

Description

Technical field: [0001] The invention relates to a traditional Chinese medicine injection and a production process thereof, in particular to a Shenxiong powder injection or freeze-dried powder injection for injection and a preparation method thereof. Background technique: [0002] Powder injection or freeze-dried powder injection is a pharmaceutical dosage form, and according to the relevant regulations on drug management in my country, changing the dosage form is managed as a new drug research. Shenxiong original injection, and included in the national drug standards. [0003] The existing traditional Chinese medicine injection for anti-platelet aggregation and coronary artery expansion is a kind of Shenxiong injection, which is made by extracting Danshen with water, treating it with lime sulfur, ethanol-precipitating the filtrate twice, and recovering ethanol. The clear liquid containing 4g of medicinal materials, adjust the pH value, add ligustrazine hydrochloride and gl...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K9/19A61P7/02A61P9/10
Inventor 王衡新
Owner 王衡新
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